Laura Behner

TL;DR: It is shown that Nipah virus (NiV), a bat-derived highly pathogenic member of the Paramyxoviridae family, differs from mononegaviruses of the Rhabdo-, Filo- and Pneumoviraceae families by forming two types of IBs with distinct localizations, formation kinetics, and protein compositions.

TL;DR: The F protein of GH-M74a showed a functional defect that is most likely caused by impaired trafficking leading to less efficient proteolytic activation and surface expression, and was compared with the glycoproteins of Nipah virus (NiV), a well-characterized pathogenic member of the henipavirus genus.

TL;DR: The sequence of fruit bat tetherin is reported and it is shown that its expression is IFN stimulated and associated with strong antiviral activity, which identifies tetherin as an antiviral effector of innate immune responses in fruit bats, which might allow these animals to control infection with NiV and potentially other viruses that cause severe disease in humans.

TL;DR: It is revealed that NiV growth substantially differs in primary cells between pigs and humans, with a more rapid spread of infection in human airway epithelia.

TL;DR: It is revealed that the nuclear import of M is ubiquitous, because MNESmut was retained in the nuclei of all cell types tested and it is interesting to note that the transport-defective MNESMut was recruited to IBperi, which provides first evidence that IBPeri are functionally relevant aggresome-like compartments.