L
Lucie Sauerhering
Researcher at University of Marburg
Publications - 22
Citations - 2688
Lucie Sauerhering is an academic researcher from University of Marburg. The author has contributed to research in topics: Medicine & Viral replication. The author has an hindex of 8, co-authored 17 publications receiving 1691 citations.
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Journal ArticleDOI
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
Linlin Zhang,Daizong Lin,Xinyuanyuan Sun,Ute Curth,Christian Drosten,Lucie Sauerhering,Stephan Becker,Katharina Rox,Rolf Hilgenfeld +8 more
TL;DR: The pharmacokinetic characterization of the optimized inhibitor reveals a pronounced lung tropism and suitability for administration by the inhalative route and work that may provide a basis for development of anticoronaviral drugs.
Journal ArticleDOI
Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment
Sandra Diederich,Lucie Sauerhering,Michael Weis,Hermann C. Altmeppen,Norbert Schaschke,Thomas Reinheckel,Stephanie Erbar,Andrea Maisner +7 more
TL;DR: This study shows for the first time that endosomal cathepsin B can play a functional role in the activation of highly pathogenic NiV.
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Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA-SARS-2-S in preclinical vaccination.
Alina Tscherne,Jan Hendrik Schwarz,Cornelius Rohde,Alexandra Kupke,Georgia Kalodimou,Leonard Limpinsel,Nisreen M.A. Okba,Berislav Bošnjak,Inga Sandrock,Ivan Odak,Sandro Halwe,Lucie Sauerhering,Katrin Brosinski,Nan Liangliang,Elke R. Duell,Sylvia Jany,Astrid Freudenstein,Jörg C. Schmidt,Anke Werner,Michelle Gellhorn Serra,Michael Klüver,Wolfgang Guggemos,M Seilmaier,Clemens-Martin Wendtner,Reinhold Förster,Bart L. Haagmans,Stephan Becker,Gerd Sutter,Asisa Volz,Asisa Volz +29 more
TL;DR: In this article, a vector vaccine based on modified vaccinia virus Ankara (MVA) against the Middle East respiratory syndrome coronavirus (MERS-CoV), which causes an infection in humans similar to SARS and COVID-19, was proposed.
Journal ArticleDOI
Nipah Virus Entry and Egress from Polarized Epithelial Cells
Boris Lamp,Erik Dietzel,Larissa Kolesnikova,Lucie Sauerhering,Stephanie Erbar,Hana M. Weingartl,Andrea Maisner +6 more
TL;DR: It is shown for the first time that NiV can infect polarized kidney epithelial cells (MDCK) from both cell surfaces, while virus release is primarily restricted to the apical plasma membrane.
Journal ArticleDOI
Nipah virus induces two inclusion body populations: Identification of novel inclusions at the plasma membrane.
Marc Ringel,Anja Heiner,Laura Behner,Sandro Halwe,Lucie Sauerhering,Nico Becker,Erik Dietzel,Bevan Sawatsky,Larissa Kolesnikova,Andrea Maisner +9 more
TL;DR: It is shown that Nipah virus (NiV), a bat-derived highly pathogenic member of the Paramyxoviridae family, differs from mononegaviruses of the Rhabdo-, Filo- and Pneumoviraceae families by forming two types of IBs with distinct localizations, formation kinetics, and protein compositions.