L
Laura Bonifaz
Researcher at Rockefeller University
Publications - 21
Citations - 4699
Laura Bonifaz is an academic researcher from Rockefeller University. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 10, co-authored 11 publications receiving 4533 citations. Previous affiliations of Laura Bonifaz include Mexican Social Security Institute.
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Journal ArticleDOI
Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance
Laura Bonifaz,David P. Bonnyay,Karsten Mahnke,Karsten Mahnke,Miguel Rivera,Michel C. Nussenzweig,Michel C. Nussenzweig,Ralph M. Steinman +7 more
TL;DR: DEC-205 provides an efficient receptor-based mechanism for dendritic cells to process proteins for MHC class I presentation in vivo, leading to tolerance in the steady state and immunity after DC maturation.
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In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination
Laura Bonifaz,David P. Bonnyay,Anna Charalambous,Dara I. Darguste,Shin-ichiro Fujii,Helena Soares,Marie K. Brimnes,Bruno Moltedo,Thomas M. Moran,Ralph M. Steinman +9 more
TL;DR: By better harnessing the immunizing functions of maturing dendritic cells, antibody-mediated antigen targeting via the DEC-205 receptor increases the efficiency of vaccination for T cell immunity, including systemic and mucosal resistance in disease models.
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Activation of Natural Killer T Cells by α-Galactosylceramide Rapidly Induces the Full Maturation of Dendritic Cells In Vivo and Thereby Acts as an Adjuvant for Combined CD4 and CD8 T Cell Immunity to a Coadministered Protein
TL;DR: A single dose of αGalCer rapidly stimulates the full maturation of dendritic cells in situ, and this accounts for the induction of combined Th1 CD4+ and CD8+ T cell immunity to a coadministered protein.
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Dendritic cell function in vivo during the steady state: a role in peripheral tolerance.
Ralph M. Steinman,Daniel Hawiger,Kang Liu,Laura Bonifaz,David P. Bonnyay,Karsten Mahnke,Tomonori Iyoda,Jeffrey V. Ravetch,Madhav V. Dhodapkar,Kayo Inaba,Michel C. Nussenzweig +10 more
TL;DR: It is proposed that dendritic cells play a major role in defining immunologic self, not only centrally in the thymus but also in the periphery, and overcomes at least some of the risk of developing autoimmunity and chronic inflammation.
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Immature, but not inactive: the tolerogenic function of immature dendritic cells
TL;DR: This review summarizes the current knowledge about the immunoregulatory role of immature DC that might act as guardians for the induction and maintenance of T cell tolerance in the periphery.