A
Anna Charalambous
Researcher at University of Cyprus
Publications - 25
Citations - 2137
Anna Charalambous is an academic researcher from University of Cyprus. The author has contributed to research in topics: Medicine & Antigen. The author has an hindex of 11, co-authored 19 publications receiving 2019 citations. Previous affiliations of Anna Charalambous include Rockefeller University.
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Journal ArticleDOI
In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination
Laura Bonifaz,David P. Bonnyay,Anna Charalambous,Dara I. Darguste,Shin-ichiro Fujii,Helena Soares,Marie K. Brimnes,Bruno Moltedo,Thomas M. Moran,Ralph M. Steinman +9 more
TL;DR: By better harnessing the immunizing functions of maturing dendritic cells, antibody-mediated antigen targeting via the DEC-205 receptor increases the efficiency of vaccination for T cell immunity, including systemic and mucosal resistance in disease models.
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Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications.
Radek Spisek,Anna Charalambous,Amitabha Mazumder,David H. Vesole,Sundar Jagannath,Madhav V. Dhodapkar +5 more
TL;DR: The uptake of human myeloma cells by dendritic cells after tumor cell death by bortezomib leads to the induction of antitumor immunity, including against primary tumor cells, without the need for any additional adjuvants.
Journal ArticleDOI
Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder.
TL;DR: Haplotype transmission comparisons point to a functionally distinct BDNF haplotype uniquely marked by the rare Met66 allele, which is undertransmitted and likely confers a protective effect in OCD and other psychiatric disorders.
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The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen
Young-Sun Kang,Jae Y. Kim,Sandra A. Bruening,Maggi Pack,Anna Charalambous,Alla Pritsker,Thomas M. Moran,Jutta M. Loeffler,Ralph M. Steinman,Chae Gyu Park +9 more
TL;DR: It is found that encapsulated Streptococcus pneumoniae are rapidly cleared by these macrophages from the bloodstream, and that capture also takes place when different cell lines express SIGN-R1 after transfection.
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Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells
Kang Liu,Juliana Idoyaga,Anna Charalambous,Shin-ichiro Fujii,Anthony J. Bonito,José Mordoh,Rosa Wainstok,Rosa Wainstok,Xue-Feng Bai,Yang Liu,Ralph M. Steinman +10 more
TL;DR: Mature tumor capturing DCs stimulated the differentiation of P1A tumor antigen-specific, CD8+ T cells and uniquely transferred tumor resistance to naive mice, and the access of dying tumor cells to DCs that are maturing to activated NKT cells efficiently induces long-lived adaptive resistance.