Laura Mangiarini

TL;DR: This study represents the analysis of the preliminary data collected for the evaluation of current status of the iron chelation practice in the Italian thalassaemic population and describes how therapeutic interventions can widely differ in the different patients' age groups.

TL;DR: This narrative review provides an overview of the roles of clinical research networks in pediatric drug development and describes how sustainable networks benefit all stakeholders by providing a multifunctional platform that promotes the quality and timeliness of clinical drug development.

TL;DR: The impact of developmental growth on the pharmacokinetics of deferiprone in children aged <6 years is assessed using a population approach based on pharmacokinetic bridging concepts and comparable systemic exposure is achieved in children and adults after similar dose levels in mg kg-1.

TL;DR: This analysis confirms the importance of patients’ registries for the collection of large datasets and the need for dedicated ‘specialized centers’ equipped to provide the best standard treatment to patients.

TL;DR: The GAPP-2 study hopes to provide evidence that the combination of morphine and gabapentin will provide better analgesia than morphine alone and will be safe and obtain confirmation of the recommended pediatric dose.