Laura Martorano

TL;DR: The zebrafish mpv17−/− mutant shows a severe mitochondrial phenotype with ultrastructural alterations and oxidative phosphorylation impairment, linking the loss of Mpv17 to pyrimidine de novo synthesis and opening a new simple therapeutic approach for MPV17-related MDS.

TL;DR: The findings indicate that Jak/Stat3 signalling is needed for intestinal stem cell maintenance and possibly crucial in controlling Wnt/β-catenin-dependent colorectal cancer cell proliferation.

TL;DR: In this paper, it was shown that import of STAT3 inside mitochondria requires Y705 phosphorylation by Jak, whereas its mitochondrial transcriptional activity, as well as its effect on proliferation, depends on the MAPK target S727.

TL;DR: In this paper, the DNA polymerase gamma (Polg) is a nuclear-encoded enzyme involved in DNA replication in animal mitochondria and mutations in the POLG gene underlie a set of mitochondrial diseases characterized by mtDNA depletion or deletion and multiorgan defects, for which an effective therapy is still needed.

TL;DR: It is determined in vivo that mitochondrial STAT3 regulates mtDNA transcription in embryonic and larval stem cell niches and that this activity determines their proliferation rates, and that STAT3-dependent increase of mitochondrial transcription seems independent from STAT3 binding to DNA and does not originate fromSTAT3 regulation of mtDNA replication.