A
Andrea Rasola
Researcher at University of Padua
Publications - 98
Citations - 6015
Andrea Rasola is an academic researcher from University of Padua. The author has contributed to research in topics: Mitochondrion & Mitochondrial permeability transition pore. The author has an hindex of 39, co-authored 91 publications receiving 5041 citations. Previous affiliations of Andrea Rasola include Nencki Institute of Experimental Biology & University of Udine.
Papers
More filters
Journal ArticleDOI
The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis
Andrea Rasola,Paolo Bernardi +1 more
TL;DR: Basic concepts about PTP structure, function and regulation within the framework of intracellular death signalling, and its role in disease pathogenesis are reviewed.
Journal ArticleDOI
Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis
Andrea Rasola,Paolo Bernardi +1 more
TL;DR: A rise in mitochondrial Ca(2+) can convey both apoptotic and necrotic death signals by inducing opening of the PTP, a high conductance inner membrane channel, and has important implications in the fine comprehension of the main biological routines of the cell and in disease pathogenesis.
Journal ArticleDOI
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology
Paolo Bernardi,Andrea Rasola,Andrea Rasola,Andrea Rasola,Michael Forte,Giovanna Lippe,Giovanna Lippe,Giovanna Lippe +7 more
TL;DR: Structural and functional features of F-ATP synthases are discussed that may provide clues to its transition from an energy-conserving into anEnergy-dissipating device as well as recent advances on signal transduction to the PTP and on its role in cellular pathophysiology.
Journal ArticleDOI
Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels
Federica Chiara,Diego Castellaro,Oriano Marin,Valeria Petronilli,William S.A. Brusilow,Magdalena Juhaszova,Steven J. Sollott,Michael Forte,Paolo Bernardi,Andrea Rasola +9 more
TL;DR: It is shown that a hexokinase II N-terminal peptide selectively detaches hexokin enzyme II from mitochondria and activates apoptosis, a permeability transition pore opening signal that results in cell death and does not require the voltage-dependent anion channel.
Journal ArticleDOI
Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation
Anna Pastò,Chiara Bellio,Giorgia Pilotto,Vincenzo Ciminale,Micol Silic-Benussi,Giulia Guzzo,Andrea Rasola,Chiara Frasson,Giorgia Nardo,Elisabetta Zulato,Maria Ornella Nicoletto,Mariangela Manicone,Stefano Indraccolo,Alberto Amadori +13 more
TL;DR: The metabolic profile of cancer stem cells isolated from patients with epithelial ovarian cancer showed higher mitochondrial reactive oxygen species (ROS) production and elevated membrane potential, and underwent apoptosis upon inhibition of the mitochondrial respiratory chain.