L
Laura Nistico
Researcher at Allegheny General Hospital
Publications - 39
Citations - 2951
Laura Nistico is an academic researcher from Allegheny General Hospital. The author has contributed to research in topics: Biofilm & Bacteria. The author has an hindex of 23, co-authored 37 publications receiving 2719 citations. Previous affiliations of Laura Nistico include Drexel University.
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Journal ArticleDOI
Direct Detection of Bacterial Biofilms on the Middle-Ear Mucosa of Children With Chronic Otitis Media
Luanne Hall-Stoodley,Fen Z. Hu,Fen Z. Hu,Armin Gieseke,Armin Gieseke,Laura Nistico,Duc Nguyen,Jay Hayes,Michael L. Forbes,David P. Greenberg,Bethany Dice,Amy Burrows,P. Ashley Wackym,Paul Stoodley,Paul Stoodley,J. Christopher Post,J. Christopher Post,Garth D. Ehrlich,Garth D. Ehrlich,Joseph E. Kerschner +19 more
TL;DR: Direct detection of biofilms on MEM biopsy specimens from children with OME and recurrent OM supports the hypothesis that these chronic middle-ear disorders are biofilm-related.
Journal ArticleDOI
Characterization of biofilm matrix, degradation by DNase treatment and evidence of capsule downregulation in Streptococcus pneumoniae clinical isolates
Luanne Hall-Stoodley,Laura Nistico,Karthik Sambanthamoorthy,Bethany Dice,Duc Nguyen,William J. Mershon,Candice Johnson,Fen Z. Hu,Paul Stoodley,Garth D. Ehrlich,J. Christopher Post +10 more
TL;DR: All pneumococcal strains developed biofilms that exhibited extracellular dsDNA in the biofilm matrix, however strains with a high BFI correlated with greater carbohydrate-associated structural complexity and antibiotic resistance, however all strains of S. pneumoniae showed downregulation of the cpsA gene during biofilm growth compared to planktonic culture, regardless of BFI ranking.
Journal ArticleDOI
The role of biofilms in otolaryngologic infections: update 2007.
TL;DR: The recognition that chronic otolaryngologic bacterial infections are biofilm related has been the impetus for the development of new technologies for the study of biofilms and their prevention and treatment.
Journal ArticleDOI
Adenoid Reservoir for Pathogenic Biofilm Bacteria
Laura Nistico,Rachael Kreft,Armin Gieseke,James M. Coticchia,Amy Burrows,Pawjai Khampang,Y. Liu,Joseph E. Kerschner,J.C. Post,J.C. Post,S. Lonergan,Rangarajan Sampath,Fen Z. Hu,Fen Z. Hu,Garth D. Ehrlich,Garth D. Ehrlich,Paul Stoodley,Paul Stoodley,Paul Stoodley,Luanne Hall-Stoodley,Luanne Hall-Stoodley,Luanne Hall-Stoodley +21 more
TL;DR: Fluorescence in situ hybridization, lectin binding, and the use of antibodies specific for host epithelial cells demonstrated that pathogens were aggregated, surrounded by a carbohydrate matrix, and localized on and within the epithelial cell surface, which is consistent with criteria for bacterial biofilms.
Journal ArticleDOI
Direct demonstration of viable Staphylococcus aureus biofilms in an infected total joint arthroplasty. A case report.
Paul Stoodley,Laura Nistico,Sandra Johnson,Leslie-Anne Lasko,Mark E. Baratz,Vikram Gahlot,Garth D. Ehrlich,Sandeep Kathju +7 more
TL;DR: In this paper, the authors describe the case of a patient who had chronic recurring symptoms of infection that persisted for years following total elbow arthroplasty despite numerous medical and surgical interventions.