Laura P. Hale

TL;DR: The composition and spatial organization of the mucosal flora in biopsy specimens from patients with inflammatory bowel disease, self-limiting colitis, irritable-bowel syndrome, and healthy controls were investigated by using a broad range of fluorescent bacterial group-specific rRNA-targeted oligonucleotide probes.

TL;DR: These data show a selective in vivo requirement for Glut1 in metabolic reprogramming of CD4 T cell activation and Teff expansion and survival and a selection of Treg cells that appeared functionally unaffected and able to suppress Teff, irrespective of Glut 1 expression.

TL;DR: This review brings together numerous divergent lines of investigation on the CD44 molecule, review the many functional roles attributed to it, and presents a unifying view of how, with numerous ligands, it may participate in several areas of normal immune cell function.

TL;DR: In this article, the authors evaluated CD4+ T cell populations in murine models and determined that inflammatory T cells maintain high expression of glycolytic genes, while Tregs are oxidative and require mitochondrial electron transport to proliferate and differentiate.

TL;DR: Five specific monoclonal antibodies (mAbs) developed through long-term immunization protocols using the EGFRvIII-specific synthetic peptide and the intact variant in different formats that maintained secondary and tertiary conformation are reported, establishing that EGfrvIII is truly tumor specific for subsets of breast carcinomas and for previously reported non-small cell lung carcinomas