Laura Yamokoski

TL;DR: Therapy to reduce volume overload during hospitalization for heart failure led to marked improvement in signs and symptoms of elevated filling pressures with or without the PAC, which reached significance for the time trade-off at all time points after randomization.

TL;DR: Nurses' estimations of survival in discharged, advanced-stage heart failure patients were superior to either physicians' or model-based predictions, but this may have resulted from the fact that the rehospitalization estimates did not include the death risk.

TL;DR: In patients hospitalized with severe HF decompensation, HRQOL is seriously impaired but improves substantially within 1 month for most patients and remains improved for 6 months.

TL;DR: Five clinical variables that are independently associated with improvement of left ventricular ejection fraction to normal or near-normal values with medical therapy alone were identified and may be used to discriminate between patients in whom ventricular function will normalize with medical Therapy alone and those who will require more aggressive pharmacologic or device therapy.

TL;DR: These changes in myocardial gene expression support the occurrence of reverse remodeling during chronic CRT, similar to those reported previously with beta-blockade, but were seen on top of standard drug therapies for heart failure.