Laurel S. Almer

TL;DR: Comparisons of the MIC frequency distributions of the study drugs against the isolates obtained during the three sampling periods encompassing this investigation revealed no evidence of changes in the in vitro activities of the fluoroquinolones.

TL;DR: The profile of ABT-492 suggested that it may be a useful agent for the treatment of community-acquired respiratory tract infections, as well as infections of the urinary tract, bloodstream, and skin and skin structure and nosocomial lung infections.

TL;DR: ABT-773 has superior activity against macrolide-resistant streptococci compared to that of telithromycin and lacks activity against constitutive macrolides-resistant Staphylococcus aureus but had good activities against inducibly resistant StaphlyococcusAureus.

TL;DR: ABT-492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolysis, nonfermentative, gram-negative organisms.

TL;DR: It is indicated that MRSA from adult subjects with community respiratory infections have similar antimicrobial susceptibility profiles and resistance mechanisms as nosocomial MRSA, and represent a genetically diverse group.