Z
Zhensheng Cao
Researcher at Abbott Laboratories
Publications - 7
Citations - 397
Zhensheng Cao is an academic researcher from Abbott Laboratories. The author has contributed to research in topics: Ketolide & Streptococcus pneumoniae. The author has an hindex of 7, co-authored 7 publications receiving 389 citations.
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Journal ArticleDOI
Novel Erythromycin Derivatives with Aryl Groups Tethered to the C-6 Position Are Potent Protein Synthesis Inhibitors and Active against Multidrug-Resistant Respiratory Pathogens
Zhenkun Ma,Richard F. Clark,Antony A Brazzale,Sanyi Wang,Rupp Michael J,Leping Li,George Griesgraber,Suoming Zhang,Hong Yong,Ly Tam Phan,Peter A. Nemoto,Daniel T. W. Chu,Jacob J. Plattner,Xiaolin Zhang,Ping Zhong,Zhensheng Cao,Angela M. Nilius,Virginia D. Shortridge,Robert K. Flamm,Michael J. Mitten,J. Meulbroek,Patty Ewing,Jeff Alder,Yat Sun Or +23 more
TL;DR: Preliminary mechanistic studies indicated that the new macrolides are potent protein synthesis inhibitors, which interact with methylated ribosomes isolated from resistant organisms, and exhibited excellent in vivo efficacy and balanced pharmacokinetic profiles.
Journal ArticleDOI
Studies of the novel ketolide ABT-773: transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae.
John O. Capobianco,Zhensheng Cao,Virginia D. Shortridge,Zhenkun Ma,Robert K. Flamm,Ping Zhong +5 more
TL;DR: The ketolide ABT-773, which has a 3-keto group and no l-cladinose sugar, represents a new class of drugs with in vitro activity against a variety of resistant bacteria, and demonstrated tighter ribosome binding of ABt-773 than erythromycin.
Journal ArticleDOI
Comparison of in vitro activities of ABT-773 and telithromycin against macrolide-susceptible and -resistant streptococci and staphylococci.
Virginia D. Shortridge,Ping Zhong,Zhensheng Cao,Jill Beyer,Laurel S. Almer,Nancy C. Ramer,Stella Z. Doktor,Robert K. Flamm +7 more
TL;DR: ABT-773 has superior activity against macrolide-resistant streptococci compared to that of telithromycin and lacks activity against constitutive macrolides-resistant Staphylococcus aureus but had good activities against inducibly resistant StaphlyococcusAureus.
Journal ArticleDOI
Induction of ribosome methylation in MLS-resistant Streptococcus pneumoniae by macrolides and ketolides.
Ping Zhong,Zhensheng Cao,Rachel Hammond,Yan Chen,J. Beyer,Virginia D. Shortridge,L.Y. Phan,Steven D. Pratt,John Capobianco,Karl A. Reich,Robert K. Flamm,Yat-Sun Or,Leonard Katz +12 more
TL;DR: It is shown here that the basal levels of ribosomal methylation vary from strain to strain, and the level of rRNA methylation can be strongly induced by erythromycin, azithromycin and TE-802, resulting in high-level of resistance to these compounds.
Journal ArticleDOI
Novel Antibacterial Class
Peter J. Dandliker,Steve D. Pratt,Angela M. Nilius,Candace Black-Schaefer,Xiaoan Ruan,Danli L. Towne,Richard F. Clark,Erika E. Englund,Rolf Wagner,Moshe Weitzberg,Linda E. Chovan,Robert K. Hickman,Melissa M. Daly,Stephan J. Kakavas,Ping Zhong,Zhensheng Cao,Caroline A. David,Xiaoling Xuei,Claude G. Lerner,Niru B. Soni,Mai Bui,Linus L. Shen,Yingna Cai,Philip J. Merta,Anne Y. Saiki,Bruce A. Beutel +25 more
TL;DR: The discovery and characterization of a novel ribosome inhibitor (NRI) class that exhibits selective and broad-spectrum antibacterial activity and evidence that the NRIs inhibit bacterial protein synthesis by inhibiting ribosomes is reported.