L
Laurence Chiche
Researcher at University of Caen Lower Normandy
Publications - 124
Citations - 6568
Laurence Chiche is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Liver transplantation & Medicine. The author has an hindex of 37, co-authored 107 publications receiving 5710 citations.
Papers
More filters
Journal ArticleDOI
Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients.
TL;DR: The best indication for transplantation seems to be patients with small and uninodular or binodular tumors; until now, these patients were considered to be the best candidates for resection.
Journal ArticleDOI
Genotype-phenotype correlation in hepatocellular adenoma: new classification and relationship with HCC.
Jessica Zucman-Rossi,Emmanuelle Jeannot,Jeanne Tran Van Nhieu,Jean-Yves Scoazec,Catherine Guettier,Sandra Rebouissou,Yannick Bacq,Emmanuelle Leteurtre,Valérie Paradis,Sophie Michalak,Dominique Wendum,Laurence Chiche,Monique Fabre,Lucille Mellottee,Christophe Laurent,Christian Partensky,Denis Castaing,Elie Serge Zafrani,Pierre Laurent-Puig,Charles Balabaud,Paulette Bioulac-Sage +20 more
TL;DR: The molecular and pathological classification of hepatocellular adenoma permits the identification of strong genotype–phenotype correlations and suggests that adenomas with β‐catenin activation have a higher risk of malignant transformation.
Journal ArticleDOI
Hepatic Resection for Noncolorectal Nonendocrine Liver Metastases: Analysis of 1452 Patients and Development of a Prognostic Model
René Adam,Laurence Chiche,Thomas A. Aloia,Dominique Elias,Rémy Salmon,Michel Rivoire,Daniel Jaeck,Jean Saric,Yves Patrice Le Treut,Jacques Belghiti,Georges Mantion,Gilles Mentha +11 more
TL;DR: HR for NCNELM is safe and effective, with outcomes mainly dependent on primary tumor site and histology, and a statistical model based on key prognostic factors could validate the indication for hepatic resection by predicting long-term survivals.
Journal ArticleDOI
Orthotopic liver transplantation in fulminant and subfulminant hepatitis. The Paul Brousse experience.
Henri Bismuth,Didier Samuel,Denis Castaing,René Adam,Faouzi Saliba,Marc Johann,Daniel Azoulay,Béatrice Ducot,Laurence Chiche +8 more
TL;DR: Orthotopic liver transplantation is an effective treatment in fulminant hepatitis and use of high-risk grafts permitted transplantation of 83% of patients, but was responsible for higher mortality.
Journal ArticleDOI
Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation
Jean-Charles Nault,Jean-Charles Nault,Gabrielle Couchy,Charles Balabaud,Guillaume Morcrette,Stefano Caruso,Jean-Frédéric Blanc,Yannick Bacq,Julien Calderaro,Valérie Paradis,Jeanne Ramos,Jean-Yves Scoazec,Viviane Gnemmi,Nathalie Sturm,Catherine Guettier,Monique Fabre,Eric Savier,Laurence Chiche,Philippe Labrune,Janick Selves,Dominique Wendum,Camilla Pilati,Alexis Laurent,Anne de Muret,Brigitte Le Bail,Sandra Rebouissou,Sandrine Imbeaud,Christophe Laurent,Jean Saric,Nora Frulio,Claire Castain,Fanny Dujardin,Zin Benchellal,Pascal Bourlier,Daniel Azoulay,Alain Luciani,Georges-Philippe Pageaux,Jean-Michel Fabre,Valérie Vilgrain,Jacques Belghiti,Brigitte Bancel,Emmanuel Boleslawski,Christophe Letoublon,Jean-Christophe Vaillant,Sophie Prevot,Denis Castaing,Emmanuel Jacquemin,Jean-Marie Péron,Alberto Quaglia,François Paye,Luigi Terraciano,Vincenzo Mazzaferro,Marie Christine Saint Paul,Benoit Terris,Paulette Bioulac-Sage,Eric Letouzé,Jessica Zucman-Rossi +56 more
TL;DR: Using sequencing and gene expression analyses, a subgroup of HCA is identified by fusion of the INHBE and GLI1 genes and activation of sonic hedgehog pathway associated with malignant transformation and bleeding, respectively.