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Laurence Nicod

Researcher at University of Franche-Comté

Publications -  31
Citations -  673

Laurence Nicod is an academic researcher from University of Franche-Comté. The author has contributed to research in topics: Human serum albumin & HaCaT. The author has an hindex of 13, co-authored 31 publications receiving 591 citations.

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Glyphosate-induced stiffening of HaCaT keratinocytes, a Peak Force Tapping study on living cells

TL;DR: These experiments indicate glyphosate induces cell membrane stiffening, and the appearance of cytoskeleton structures at a subcellular level, for low cytotoxic concentrations whereas cells exposed to IC50 (inhibitory concentration 50%) treatment exhibit control-like mechanical behavior despite obvious membrane damages.
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Synthesis and antioxidant activity evaluation of new hexahydropyrimido[5,4-c]quinoline-2,5-diones and 2-thioxohexahydropyrimido[5,4-c]quinoline-5-ones obtained by Biginelli reaction in two steps.

TL;DR: New hexahydropyrimido[5,4-c]quinoline-2,5-diones and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and scavenging effect on hydroxyl radicals show that the compounds containing thiourea moiety have better activity.
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In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo

TL;DR: The in vitro cytotoxicity bioassays on human epidermic cell line HaCaT revealed the major role played in synergy by neral and geranial in the overall toxicity showed by the citratus oil sample tested in this work.
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Glyphosate-induced antioxidant imbalance in HaCaT: The protective effect of Vitamins C and E.

TL;DR: In vitro data indicated that VitC and VitE might have preventive effects against deleterious cutaneous cell damage caused by glyphosate-induced epidermal antioxidant impairment, and increased lipid peroxidation in Roundup 3 plus(®)-treated keratinocytes.
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Storage and qualification of viable intact human amniotic graft and technology transfer to a tissue bank.

TL;DR: Results show no dramatic decrease in cell viability in cultured hAM as compared to cryopreserved hAM, but tissue structure alterations were observed with both storage conditions, and Histological and immunohistochemical data highlight that tissue damage was associated with significantly modified protein expression, which could lead to a possible loss of differentiation potential.