Laurent P. Audoly

TL;DR: HMGB1, a nuclear DNA-binding protein released from necrotic cells, was an essential component of DNA-containing immune complexes that stimulated cytokine production through a TLR9–MyD88 pathway involving the multivalent receptor RAGE.

TL;DR: In this article, the role of microsomal PGE synthase 1 (mPGES1) in the pathogenesis of human rheumatoid arthritis was identified and shown to be responsible for producing PGE2 that mediates acute pain during an inflammatory response.

TL;DR: Data indicate that ATP does act via the P2X7R to affect leukocyte function and that it can serve as an important component of an in vivo inflammatory response.

TL;DR: It is shown that the purinoceptor P2Y1 is required for platelet shape change in response to ADP and is also a principal receptor mediating ADP-induced platelet aggregation, which supports the hypothesis that the ATP receptor P2y1 is a principal receptors mediating both physiologic and pathological ADp-induced processes in platelets.

TL;DR: PGE2 contributes to disease progression at least in part by binding to the EP4 receptor, and antagonists of this receptor might therefore provide novel agents for the treatment of RA.