C
Cherilyn M. Sirois
Researcher at University of Massachusetts Medical School
Publications - 22
Citations - 8084
Cherilyn M. Sirois is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: RAGE (receptor) & Immune system. The author has an hindex of 12, co-authored 22 publications receiving 7138 citations. Previous affiliations of Cherilyn M. Sirois include Universidad de las Américas Puebla & College of Health Sciences, Bahrain.
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Journal ArticleDOI
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Peter Duewell,Hajime Kono,Katey J. Rayner,Katey J. Rayner,Cherilyn M. Sirois,Gregory I. Vladimer,Franz Bauernfeind,George S. Abela,Luigi Franchi,Guillermo Gabriel Nuñez,Max Schnurr,Terje Espevik,Egil Lien,Katherine A. Fitzgerald,Kenneth L. Rock,Kathryn J. Moore,Kathryn J. Moore,Samuel D. Wright,Veit Hornung,Eicke Latz,Eicke Latz +20 more
TL;DR: It is shown that cholesterol crystals activate the NLRP3 inflammasome in phagocytes in vitro in a process that involves phagolysosomal damage and that crystalline cholesterol acts as an endogenous danger signal and its deposition in arteries or elsewhere is an early cause rather than a late consequence of inflammation.
Journal ArticleDOI
Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals (Nature (2010) 464 (1357-1361))
Peter Duewell,Hajime Kono,Katey J. Rayner,Cherilyn M. Sirois,Gregory I. Vladimer,Franz Bauernfeind,George S. Abela,Luigi Franchi,Gabriel Núñez,Max Schnurr,Terje Espevik,Egil Lien,Katherine A. Fitzgerald,Kenneth L. Rock,Kathryn J. Moore,Samuel D. Wright,Veit Hornung,Eicke Latz +17 more
TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is a two-step process, not a single step, like in the previous version of this paper.
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IFI16 is an innate immune sensor for intracellular DNA.
Leonie Unterholzner,Sinead E. Keating,Marcin Baran,Kristy A. Horan,Søren B. Jensen,Søren B. Jensen,Shrutie Sharma,Cherilyn M. Sirois,Tengchuan Jin,Eicke Latz,Eicke Latz,T. Sam Xiao,Katherine A. Fitzgerald,Søren R. Paludan,Andrew G. Bowie +14 more
TL;DR: IFI16 (p204) is the first PYHIN protein to their knowledge shown to be involved in IFN-β induction and forms a new family of innate DNA sensors the authors call 'AIM2-like receptors' (ALRs).
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Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Jane Tian,Ana M. Avalos,Su-Yau Mao,Bo Chen,Kannaki Senthil,Herren Wu,Peggy Parroche,Stacey Drabic,Douglas T. Golenbock,Cherilyn M. Sirois,Jing Hua,Ling-Ling An,Laurent P. Audoly,Greg La Rosa,Angelika Bierhaus,Peter Naworth,Ann Marshak-Rothstein,Mary K. Crow,Katherine A. Fitzgerald,Eicke Latz,Peter A. Kiener,Anthony J. Coyle +21 more
TL;DR: HMGB1, a nuclear DNA-binding protein released from necrotic cells, was an essential component of DNA-containing immune complexes that stimulated cytokine production through a TLR9–MyD88 pathway involving the multivalent receptor RAGE.
Journal ArticleDOI
Ligand-induced conformational changes allosterically activate Toll-like receptor 9
Eicke Latz,Anjali Verma,Alberto Visintin,Mei Gong,Cherilyn M. Sirois,Dionne C.G. Klein,Brian G. Monks,C. James McKnight,Marc Lamphier,W. Paul Duprex,Terje Espevik,Douglas T. Golenbock +11 more
TL;DR: It is shown that Toll-like receptor 9 bound to stimulatory and inhibitory DNA; however, only stimulatory DNA led to substantial conformational changes in the TLR9 ectodomain, indicating thatTLR9 activation is regulated by conformationalChanges induced by DNA containing CpG.