L
Lawrence Feinman
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 19
Citations - 1162
Lawrence Feinman is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Ethanol metabolism & Alcoholic liver disease. The author has an hindex of 10, co-authored 19 publications receiving 1149 citations. Previous affiliations of Lawrence Feinman include United States Department of Veterans Affairs & City University of New York.
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High blood acetaldehyde levels after ethanol administration. Difference between alcoholic and nonalcoholic subjects.
TL;DR: The ethanol concentration at which this fall of blood acetaldehyde occurred suggests desaturation of an ethanol oxidizing system other than alcohol dehydrogenase and indicates that at high ethanol blood levels, such a system contributes to ethanol oxidation.
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Difference in Hepatic Metabolism of Long- and Medium-Chain Fatty Acids: the Role of Fatty Acid Chain Length in the Production of the Alcoholic Fatty Liver*
TL;DR: MCFA was much more oxidized and reciprocally much less Esterified than LCFA, with a 100-fold difference in the ratio of esterified lipid-(14)C to (14)CO(2), and in hepatic microsomal fractions incubated with alpha-glycerophosphate, octanoate was much less esterify than palmitate.
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Hepatic Collagen Metabolism: Effect of Alcohol Consumption in Rats and Baboons
TL;DR: Activity of collagen proline hydroxylase in the liver is stimulated, and incorporation of proline into collagen hydroxyproline in rat liver slices is significantly enhanced, indicating that increased synthesis is responsible, in part, for the collagen accumulation.
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Mammalian collagenase increases in early alcoholic liver disease and decreases with cirrhosis.
Katsuya Maruyama,Lawrence Feinman,Zev Fainsilber,Masayuki Nakano,Isao Okazaki,Charles S. Lieber +5 more
TL;DR: The findings suggest that the development of cirrhosis is coincident with, or favored by a failure of hepatic collagen degradative enzymes to keep pace with liver protein synthesis.