L
Lawrence M. Schwartz
Researcher at University of Massachusetts Amherst
Publications - 157
Citations - 10071
Lawrence M. Schwartz is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: Programmed cell death & Apoptosis. The author has an hindex of 51, co-authored 155 publications receiving 9713 citations. Previous affiliations of Lawrence M. Schwartz include University of North Carolina at Chapel Hill & Medical College of Wisconsin.
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Journal ArticleDOI
Apoptotic Signals Delivered Through the T-Cell Receptor of a T-Cell Hybrid Require the Immediate-Early Gene Nur77
TL;DR: Nur77, a zinc-finger transcription factor, is expressed in response to TCR engagement in immature T cells and T-cell hybrids andAntisense inhibition of nur77 expression prevents apoptosis in TCR-stimulated cells, and data support a role for nur 77 in cell death that may be distinct from that of activation.
Journal ArticleDOI
Do all programmed cell deaths occur via apoptosis
TL;DR: Comparing the patterns of cell death displayed by T cells and the intersegmental muscles is compared and it is found that they differ in terms of cell-surface morphology, nuclear ultrastructure, DNA fragmentation, and polyubiquitin gene expression.
Journal ArticleDOI
New pore-size parameter characterizing transport in porous media.
TL;DR: A well-defined geometrical parameter, $\ensuremath{\Lambda}$, related to dynamically connected pore sizes in composite materials is introduced that is also related to the dc permeability to flow of a viscous fluid.
Journal ArticleDOI
Programmed cell death, apoptosis and killer genes
TL;DR: Here, Lawrence Schwartz and Barbara Osborne define the terms and ideas relevant to the study of cell death in a way that will be accessible to investigators from all fields.
Journal ArticleDOI
Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro
Carol Milligan,David Prevette,Hiroyuki Yaginuma,Shunsaku Homma,C. Cardwellt,L.C. Fritz,Kevin J. Tomaselli,Ronald W. Oppenheim,Lawrence M. Schwartz +8 more
TL;DR: Results provide the first evidence that ICE or an ICE-like protease plays a regulatory role not only in vertebrate motoneuron death but also in the developmentally regulated deaths of other cells in vivo.