L
Lawrence Park
Researcher at National Institutes of Health
Publications - 66
Citations - 2151
Lawrence Park is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Major depressive disorder & Medicine. The author has an hindex of 21, co-authored 56 publications receiving 1414 citations. Previous affiliations of Lawrence Park include Food and Drug Administration & Harvard University.
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Journal ArticleDOI
Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine
Marc S. Lener,Mark J. Niciu,Elizabeth D. Ballard,Minkyung Park,Lawrence Park,Allison C. Nugent,Carlos A. Zarate +6 more
TL;DR: Future studies in depression will require a combination of neuroimaging approaches from which more biologically homogeneous subgroups can be identified, particularly with respect to treatment response biomarkers of glutamatergic modulation.
Journal ArticleDOI
Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects
Allison C. Nugent,Elizabeth D. Ballard,Todd D. Gould,Lawrence Park,Ruin Moaddel,Nancy E. Brutsche,Carlos A. Zarate +6 more
TL;DR: B baseline gamma power was found to moderate the relationship between post-ketamine gamma power and antidepressant response and has important implications for inferring ketamine’s mechanism of action from studies of healthy controls alone.
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Depression in the Primary Care Setting.
Lawrence Park,Carlos A. Zarate +1 more
TL;DR: A 45-year-old woman with hypothyroidism that has been treated with a stable dose of levothyroxine presents to her primary care provider with depressed mood, negative feelings about herself, poor sleep, low appetite, poor concentration, and lack of energy.
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Transcranial magnetic stimulation of the brain: guidelines for pain treatment research
Max M. Klein,Roi Treister,Tommi Raij,Alvaro Pascual-Leone,Lawrence Park,Lawrence Park,Turo Nurmikko,Frederick A. Lenz,Jean Pascal Lefaucheur,Magdalena Lang,Mark Hallett,Michael D. Fox,Merit Cudkowicz,Ann Costello,Daniel B. Carr,Samar S. Ayache,Anne Louise Oaklander +16 more
TL;DR: In this article, a workshop was held to solicit advice from experts in transcranial magnetic stimulation (TMS), pain research, and clinical trials, and the authors recommended that researchers standardize and document all TMS parameters and improve strategies for sham and double blinding.
Journal ArticleDOI
Default Mode Connectivity in Major Depressive Disorder Measured Up to 10 Days After Ketamine Administration.
Jennifer W. Evans,Joanna Szczepanik,Nancy E. Brutsche,Lawrence Park,Allison C. Nugent,Carlos A. Zarate +5 more
TL;DR: Connectivity changes in the insula in subjects with MDD suggest that ketamine may normalize the interaction between the DMN and salience networks, supporting the triple network dysfunction model of MDD.