L
Lee S. Mann
Researcher at National Institutes of Health
Publications - 16
Citations - 1355
Lee S. Mann is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Mental health & Homovanillic acid. The author has an hindex of 10, co-authored 16 publications receiving 1336 citations.
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Journal ArticleDOI
Cerebral glucography with positron tomography. Use in normal subjects and in patients with schizophrenia.
Monte S. Buchsbaum,David H. Ingvar,Robert M. Kessler,Robert N. Waters,J. Cappelletti,Daniel P. van Kammen,A. Catherine King,Jeannette L. Johnson,Ronald G. Manning,Richard W. Flynn,Lee S. Mann,William E. Bunney,Louis Sokoloff +12 more
TL;DR: Local cerebral uptake of deoxyglucose labeled with fluorine 18 was measured by positron-emission tomography in eight patients with schizophrenia and in six age-matched normal volunteers, indicating relatively lower glucose use than normal control subjects.
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Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder.
David Behar,Judith L. Rapoport,Carol J. Berg,Martha Bridge Denckla,Lee S. Mann,Christian Cox,Paul Fedio,Theodore P. Zahn,Mark G. Wolfman +8 more
TL;DR: CNS dysfunctioning in children with obsessive-compulsive disorder, with possible right cerebral involvement, is suggested, although the patients' neuropsychological test deficits and VBRs were not correlated.
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Computed Tomographic Scans in Patients With Schizophrenia, Schizoaffective, and Bipolar Affective Disorder
TL;DR: Examination of the correlations of these three CT scan measures found them to be significantly related to each other, and the similarity of CT scan results argues against ascribing these abnormalities to any one psychiatric disorder or to a specific drug effect.
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Dopamine metabolism in the cerebrospinal fluid of drug-free schizophrenic patients with and without cortical atrophy.
TL;DR: It is proposed that both state- and trait-dependent variables affect dopamine turnover, and patients without brain atrophy who had dopamine utilization above the mean showed more psychotic symptoms and shorter duration of illness, while those with dopamine below the mean had more negative symptoms.
Journal ArticleDOI
Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy
D.P. van Kammen,Lee S. Mann,D. E. Sternberg,Mika Scheinin,Philip T. Ninan,Marder,W. B. van Kammen,Ronald O. Rieder,Markku Linnoila +8 more
TL;DR: These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.