Journal ArticleDOI
Computerized tomography and neuropsychological test measures in adolescents with obsessive-compulsive disorder.
David Behar,Judith L. Rapoport,Carol J. Berg,Martha Bridge Denckla,Lee S. Mann,Christian Cox,Paul Fedio,Theodore P. Zahn,Mark G. Wolfman +8 more
Reads0
Chats0
TLDR
CNS dysfunctioning in children with obsessive-compulsive disorder, with possible right cerebral involvement, is suggested, although the patients' neuropsychological test deficits and VBRs were not correlated.Abstract:
The authors administered CAT scans and neuropsychological tests to 16 adolescents with obsessive-compulsive disorder (mean age +/- SD = 13.7 +/- 1.6 years) and 16 matched controls. The patients had a mean ventricular-brain ratio (VBR) significantly higher than the controls' and showed spatial-perceptual deficits similar to those found in patients with frontal lobe lesions. Memory, reaction time, and decision time did not differ significantly from controls'. Neurodevelopmental examination of seven patients yielded a high frequency of age-inappropriate synkinesias and left hemibody signs. These results suggest CNS dysfunctioning in children with obsessive-compulsive disorder, with possible right cerebral involvement. However, the patients' neuropsychological test deficits and VBRs were not correlated.read more
Citations
More filters
Book
Obsessive Compulsive Disorder
TL;DR: A large number of patients with OCD are diagnosed with at least some form of obsessive-compulsive disorder, which is still probably the least understood of all the major psychiatric syndromes.
Journal ArticleDOI
Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder: A Comparison With Rates in Unipolar Depression and in Normal Controls
Lewis R. Baxter,Michael E. Phelps,John C. Mazziotta,Barry H. Guze,Jeffrey M. Schwartz,Carl Selin +5 more
TL;DR: In OCD, metabolic rates were significantly increased in the left orbital gyrus and bilaterally in the caudate nuclei, and cerebral glucose metabolic patterns that differed from controls in both the symptomatic and recovered states.
Journal ArticleDOI
Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder.
TL;DR: A model is presented which describes how frontal-subcortical brain circuitry may mediate OCD symptomatology, and a hypothesis for how successful treatments may ameliorate symptoms, via their effects on circuit activity is suggested.
Journal ArticleDOI
Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder.
Susan E. Swedo,Mark B. Schapiro,Cheryl L. Grady,Deborah L. Cheslow,Henrietta L. Leonard,Anand Kumar,Robert P. Friedland,Stanley I. Rapoport,Judith L. Rapoport +8 more
TL;DR: A significant relationship between metabolic activity and both state and trait measurements of OCD and anxiety as well as the response to clomipramine hydrochloride therapy was found.
Book
Obsessive-Compulsive Disorder
TL;DR: New developments in the treatment of obsessive-compulsive disorder involve medications that work in conjuction with cognitive-behavioural therapy, the most promising of which is D-cycloserine.