L
Leen Kwanten
Researcher at Janssen Pharmaceutica
Publications - 2
Citations - 159
Leen Kwanten is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Lipid bilayer fusion & Viral load. The author has an hindex of 2, co-authored 2 publications receiving 131 citations.
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Journal ArticleDOI
Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Michael B. Battles,Johannes P. M. Langedijk,Polina Furmanova-Hollenstein,Supranee Chaiwatpongsakorn,Heather M. Costello,Leen Kwanten,Luc Vranckx,P. Vink,Steffen Jaensch,Tim H. M. Jonckers,Anil Koul,Eric Arnoult,Mark E. Peeples,Mark E. Peeples,Dirk Roymans,Jason S. McLellan +15 more
TL;DR: It is shown that therapeutic small molecules developed that bind the RSV F glycoprotein and inhibit membrane fusion bind to a three-fold-symmetric pocket within the central cavity of the metastable prefusion conformation of RSVF.
Journal ArticleDOI
Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor.
Dirk Roymans,Sarhad Alnajjar,Michael B. Battles,Panchan Sitthicharoenchai,Polina Furmanova-Hollenstein,Peter Rigaux,Joke Van den Berg,Leen Kwanten,Marcia Van Ginderen,Nick Verheyen,Luc Vranckx,Steffen Jaensch,Eric Arnoult,Richard Voorzaat,Jack M. Gallup,Alejandro Larios-Mora,Marjolein Crabbe,Dymphy Huntjens,Pierre Jean-Marie Bernard Raboisson,Johannes P. M. Langedijk,Mark R. Ackermann,Jason S. McLellan,Sandrine Vendeville,Anil Koul +23 more
TL;DR: Oral treatment of neonatal lambs with JNJ-53718678 efficiently inhibits established acute lower respiratory tract infection in the animals, even when treatment is delayed until external signs of respiratory syncytial virus illness have become visible.