L
Lei Bao
Researcher at University of Tennessee Health Science Center
Publications - 10
Citations - 833
Lei Bao is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Quantitative trait locus & Expression quantitative trait loci. The author has an hindex of 9, co-authored 10 publications receiving 806 citations.
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nsSNPAnalyzer : identifying disease-associated nonsynonymous single nucleotide polymorphisms
TL;DR: nsSNPAnalyzer, a web-based software developed for this purpose, extracts structural and evolutionary information from a query nsSNP and uses a machine learning method called Random Forest to predict the ns SNP's phenotypic effect.
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Prediction of the phenotypic effects of non-synonymous single nucleotide polymorphisms using structural and evolutionary information
TL;DR: It is found that incorporating structural information is critical to achieving good prediction accuracy when sufficient evolutionary information is not available, and for nsSNPs with insufficient evolutionary information, the method outperforms the SIFT algorithm significantly.
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PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits
TL;DR: The database integrates sequence polymorphism, phenotype and expression microarray data, and characterizes PolymiRTSs as potential candidates responsible for the quantitative trait locus (QTL) effects.
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CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators
Lei Bao,Mi Zhou,Yan-Yan Cui +2 more
TL;DR: A CTCF-binding site database is constructed to characterize experimentally identified and computationally predicted CTCf-binding sties and to facilitate the identification of candidate insulators in the query sequences submitted by users.
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Inferring gene transcriptional modulatory relations: a genetical genomics approach
Hongqiang Li,Lu Lu,Kenneth F. Manly,Elissa J. Chesler,Lei Bao,Jintao Wang,Mi Zhou,Robert W. Williams,Yan Cui +8 more
TL;DR: An efficient Bayesian approach is developed that exploits the genetical genomics method to focus computational effort on the most plausible gene modulatory networks and constructed 66 candidate networks that include all the candidate modulator genes located in the 209 statistically significant trans-acting QTL regions.