Lei Dong

TL;DR: The findings show the prevalence of kidney disease on admission and the development of AKI during hospitalization in patients with COVID-19 is high and is associated with in-hospital mortality, and clinicians should increase their awareness of kidney patients with severe CO VID-19.

TL;DR: It is reported that Ptpn11 activating mutations in the mouse bone marrow microenvironment promote the development and progression of MPN through profound detrimental effects on haematopoietic stem cells (HSCs), and CCL3 is identified as a potential therapeutic target for controlling leukaemic progression in Noonan syndrome and for improving stem cell transplantation therapy innoonan-syndrome-associated leukaemias.

TL;DR: It is found that cZNF292 silencing suppresses tube formation by inhibiting glioma cell proliferation and cell cycle progression via the Wnt/β-catenin signaling pathway and related genes.

TL;DR: This study provides novel insights into the tumor progression associated with MFN2 deficiency and suggests that the importance of mTORC2 inhibitor in the treatment ofMFN2 downregulated cancer patients is suggested.

TL;DR: A review of recent advances on the potential role of NLRP3 inflammasome activation and its ability to alleviate liver inflammation in animal models provides critical targets to suppress the development of CLD in clinical management.