L
Lei Tan
Researcher at Civil Aviation Authority of Singapore
Publications - 85
Citations - 1308
Lei Tan is an academic researcher from Civil Aviation Authority of Singapore. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 17, co-authored 74 publications receiving 835 citations. Previous affiliations of Lei Tan include Nanjing Agricultural University.
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Journal ArticleDOI
Autophagy Benefits the Replication of Newcastle Disease Virus in Chicken Cells and Tissues
Yingjie Sun,Shengqing Yu,Na Ding,Chunchun Meng,Songshu Meng,Shilei Zhang,Yuan Zhan,Xusheng Qiu,Lei Tan,Hongjun Chen,Cuiping Song,Chan Ding +11 more
TL;DR: It is demonstrated that NDV infection induced steady-state autophagy in chicken-derived DF-1 cells and in primary chicken embryo fibroblast (CEF) cells, evident through increased double- or single-membrane vesicles, the accumulation of green fluorescent protein (GFP)-LC3 dots, and the conversion ofLC3-I to LC3-II.
Journal ArticleDOI
eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote apoptosis and inflammation and support the proliferation of Newcastle disease virus
Yanrong Li,Weiyu Jiang,Qiaona Niu,Sun Yingjie,Chunchun Meng,Lei Tan,Cuiping Song,Xusheng Qiu,Ying Liao,Chan Ding +9 more
TL;DR: This study demonstrates that the induction of eIF2α-CHOP-BCL-2/JNK and IRE1α-XBP1/J NK signaling cascades promote apoptosis and cytokines secretion, and these signaling cascading support NDV proliferation.
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Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication.
Bo Gao,Xiaoqian Gong,Shouguo Fang,Wenlian Weng,Huan Wang,Hongyan Chu,Yingjie Sun,Chunchun Meng,Lei Tan,Cuiping Song,Xusheng Qiu,Weiwei Liu,Maria Forlenza,Chan Ding,Ying Liao +14 more
TL;DR: In this article, the authors demonstrated that the endoribonuclease nsp15 of the Infectious Bronchitis Virus (IBV) interferes with the formation of antiviral hub SGs by regulating the accumulation of viral dsRNA and by antagonizing the activation of PKR, eventually ensuring productive virus replication.
Journal ArticleDOI
Newcastle Disease Virus V Protein Degrades Mitochondrial Antiviral Signaling Protein To Inhibit Host Type I Interferon Production via E3 Ubiquitin Ligase RNF5.
Yingjie Sun,Hang Zheng,Shengqing Yu,Yunlei Ding,Wei Wu,Xuming Mao,Ying Liao,Chunchun Meng,Zaib Ur Rehman,Lei Tan,Cuiping Song,Xusheng Qiu,Fengyun Wu,Chan Ding +13 more
TL;DR: A novel role of NDV V protein is revealed in targeting MAVS to inhibit cellular IFN production, which reinforces the fact that the virus orchestrates the cellular antiviral response to its own benefit.
Journal ArticleDOI
Activation of the PKR/eIF2α signaling cascade inhibits replication of Newcastle disease virus
Shilei Zhang,Yingjie Sun,Hongjun Chen,Yabin Dai,Yuan Zhan,Shengqing Yu,Xusheng Qiu,Lei Tan,Cuiping Song,Chan Ding +9 more
TL;DR: In insight into NDV-host interactions for the development of candidate antiviral strategies, protein kinase R is activated by dsRNA generated by NDV infection and inhibits NDV replication by eIF2α phosphorylation.