Leif Christensen

TL;DR: It is reported here that PNA containing all four natural nucleobases hybridizes to complementary oligonucleotides obeying the Watson–Crick base-pairing rules, and thus is a true DNA mimic in terms of base- Pair recognition.

TL;DR: The preparation of mixed-sequence PNAs (PNAs containing the four natural nucleobases; thymine, cytosine, adenine, and guanine) is described, essentially following standard solid phase peptide synthesis protocols.

TL;DR: In this article, a method and an apparatus for sequentially degrading at least a portion of a polymer of backbone repeating units, the polymer having a terminal repeating unit comprised of a nucleophile and a backbone carbonyl carbon distant from the nucleophile, comprising the steps of first initiating attack of said nucleophile upon said backbone carbon by raising the energy level to activate said nucleophase for said attack, and, lastly maintaining the reaction conditions necessary for repeating steps a and b until the portion of the desired is degraded.

TL;DR: Peptide nucleic acid monomer building blocks for the introduction of G and A are prepared and used to synthesise H-T4XT5-Lys-NH2(X = G or A), which are shown by Tm measurements to recognize their complementary DNA sequences in both the parallel and anti-parallel mode.

TL;DR: In this paper, the authors proposed new therapeutic peptides, i.e. new protracted Exendin-4 compounds, pharmaceutical compositions and the use of such, and provided new peptide compositions.