Bengt Nordén

TL;DR: It is reported here that PNA containing all four natural nucleobases hybridizes to complementary oligonucleotides obeying the Watson–Crick base-pairing rules, and thus is a true DNA mimic in terms of base- Pair recognition.

TL;DR: Large difference in luminescence quantum yield between the enantiomers is interpreted in terms of slightly different intercalation geometries of the dipyridophenazine ligand, resulting in different protections from quenching by solvent water and diastereomeric differences in the interactions between enantiomer bound in contigue on DNA.

TL;DR: CD can be used to analyze chiral structures such as protein secondary structure in molecules and to probe interactions between chiral molecules and other molecule and to provide orientation information about subunits of a molecular system such as small molecules absorbed onto stretched films, flow-oriented DNAs and fibrous proteins, and lipid bilayer systems.

TL;DR: Using circular dichroism spectroscopy it is shown that two complementary PNA strands can hybridize to one another to form a helical duplex and indicate that a (deoxy)ribose phosphate backbone is not an essential requirement for the formation of double helical DNA-like structures in solution.

TL;DR: Relative viscosity experiments showed that both Delta- and Lambda-DPPZ increase the length of rod-like DNA, in a manner consistent with binding by classical intercalation, and it can be shown that there is a significant nonelectrostatic contribution to the binding constant.