L
Leif H. Finkel
Researcher at University of Pennsylvania
Publications - 75
Citations - 2435
Leif H. Finkel is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Visual cortex & Nucleus accumbens. The author has an hindex of 24, co-authored 75 publications receiving 2341 citations.
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Journal ArticleDOI
Extraction of perceptually salient contours by striate cortical networks.
Shih-Cheng Yen,Leif H. Finkel +1 more
TL;DR: The model proposes that intrinsic properties of synchronization account for the increased salience of smooth, closed contours and accounts for a range of reported psychophysical and physiological effects of contour salience.
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Ketamine modulates theta and gamma oscillations
Maciej T. Lazarewicz,Richard S. Ehrlichman,Christina R. Maxwell,Michael J. Gandal,Leif H. Finkel,Steven J. Siegel +5 more
TL;DR: The effects of ketamine on in vivo recordings from the CA3 region of mouse hippocampus referenced to the ipsilateral frontal sinus using a paired-click auditory gating paradigm support a role for NMDA receptors in mediating the balance between theta and gamma responses to sensory stimuli.
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NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron
John A. Wolf,Jason T. Moyer,Maciej T. Lazarewicz,Diego Contreras,Marianne Benoit-Marand,Patricio O'Donnell,Leif H. Finkel +6 more
TL;DR: Altering the NMDA/AMPA ratio had a profound effect on processing of afferentinput, including the ability to entrain to oscillations in afferent input in the theta range (4-12 Hz).
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N-methyl-d-aspartic acid receptor antagonist–induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia
Richard S. Ehrlichman,Michael J. Gandal,Christina R. Maxwell,Maciej T. Lazarewicz,Leif H. Finkel,Diego Contreras,Bruce I. Turetsky,Steve J. Siegel +7 more
TL;DR: Ketamine-induced alterations in EEG power spectra are consistent with abnormalities in the theta and gamma frequency ranges reported in patients with schizophrenia, and support the hypothesis that NMDAR hypofunction contributes to the deficits in schizophrenia and that the dopamine pathways alone may not account for these changes.
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Integration of distributed cortical systems by reentry: a computer simulation of interactive functionally segregated visual areas
Leif H. Finkel,Gerald M. Edelman +1 more
TL;DR: The proposed model of reentry suggests a basis for understanding how multiple visual areas as well as other cortical areas may be integrated within a distributed system.