Leif Østergaard

TL;DR: A nonparametric (singular value decomposition (SVD)) deconvolution technique produced the most robust results, giving mean gray:white flow ratio of 2.7 ± 0.5 in six normal volunteers, in excellent agreement with recent PET literature values for age‐matched subjects.

TL;DR: OSVD shows promise in providing tracer arrival timing‐insensitive flow estimates and hence a more specific indicator of ischemic injury and a technique that is made time‐shift insensitive by the use of a block‐circulant matrix for deconvolution with (oSVD) and without (cSVD) minimization of oscillation of the derived residue function.

TL;DR: Subtraction of flow‐insensitive images from flow‐sensitive images gave us flow‐weighted images with good gray‐white flow contrast in cortical gray matter as well as in the thalamus and basal ganglia, and preliminary results of brain blood flow maps.

TL;DR: MR imaging can delineate areas of altered blood flow, blood volume, and water mobility in hyperacute human stroke and Predictive models of tissue outcome may benefit by including computation of both relative cerebral blood flow and blood volume.

TL;DR: This model predicts that disturbed capillary flows may cause a condition of malignant CTTH, in which states of higher CBF display lower oxygen availability, and proposes that conditions with altered capillary morphology, such as amyloid, diabetic or hypertensive microangiopathy, and ischemia—reperfusion, may disturb CTTH and thereby flow-metabolism coupling and cerebral oxygen metabolism.