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Leila Dargahi

Researcher at Shahid Beheshti University of Medical Sciences and Health Services

Publications -  124
Citations -  2749

Leila Dargahi is an academic researcher from Shahid Beheshti University of Medical Sciences and Health Services. The author has contributed to research in topics: Neuroprotection & Internal medicine. The author has an hindex of 22, co-authored 105 publications receiving 1859 citations. Previous affiliations of Leila Dargahi include Shahid Beheshti University & Trinity College, Dublin.

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Astaxanthin: A mechanistic review on its biological activities and health benefits.

Sajad Fakhri, +3 more
- 01 Oct 2018 - 
TL;DR: A novel hypothesis is suggested for the mechanism of action of AST in neuropathic pain following spinal cord injury and the therapeutic potentials, biological activities and benefical health effects of AST are focused on.
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Insulin in the Brain: Sources, Localization and Functions

Rasoul Ghasemi, +4 more
- 01 Feb 2013 - 
TL;DR: This review summarizes the current status of knowledge of the peripheral and central sources of insulin in the brain, site-specific expression of IRs, and also neurophysiological functions of insulin including the regulation of food intake, weight control, reproduction, and cognition and memory formation and considers the neuromodulatory and neurotrophic effects of insulin.
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Glycogen synthase kinase-3 beta (GSK-3β) signaling: Implications for Parkinson's disease.

Mojtaba Golpich, +10 more
- 01 Jul 2015 - 
TL;DR: In this paper, a review of GSK-3 signaling pathways and its association with neuroinflammation is presented, highlighting the interaction between GSK3β and several cellular processes involved in the pathogenesis of Parkinson's disease, including accumulation of α-Synuclein aggregates, oxidative stress and mitochondrial dysfunction.
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FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats

Masoumeh Asle-Rousta, +5 more
- 26 Feb 2013 - 
TL;DR: Chronic daily administration of FTY720 significantly attenuated the Aβ42-induced learning and memory impairment and prevented the hippocampus neuronal damage as well as caspase-3 activation, suggesting that S1P receptors and signaling pathways may provide a potential target for the treatment of AD.
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Brain insulin dysregulation: implication for neurological and neuropsychiatric disorders.

Rasoul Ghasemi, +6 more
- 20 Jan 2013 - 
TL;DR: This review summarizes the recent findings on the involvement of insulin dysfunction in neurological disorders like Alzheimer's disease, Parkinson's disease and Huntington’s disease and also mental disorders like depression and psychosis sharing features of neuroinflammation and neurodegeneration.