L
Leila R. Martins
Researcher at Instituto de Medicina Molecular
Publications - 20
Citations - 1247
Leila R. Martins is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Leukemia & PI3K/AKT/mTOR pathway. The author has an hindex of 13, co-authored 17 publications receiving 1128 citations. Previous affiliations of Leila R. Martins include German Cancer Research Center & University of Lisbon.
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Journal ArticleDOI
Targeting CK2 Overexpression as a Novel Therapeutic Tool in Chronic Lymphocytic Leukemia.
TL;DR: The study suggests that CK2 plays an important role in the biology of CLL, and lays the groundwork for the inclusion of CK2 antagonists into future therapeutic options.
Journal ArticleDOI
In Vitro and in Vivo Targeting of Chronic Lymphocytic Leukemia Using CX-4945, a Clinical-Stage CK2-Specific Inhibitor.
Leila R. Martins,Paulo Sérgio Lucio,Alice Melão,Bruno A. Cardoso,Ryan Stansfield,Denis Drygin,Maria Gomes da Silva,João T. Barata +7 more
TL;DR: The data indicate that pharmacological inhibition of CK2 is a promising therapeutic strategy in CLL that may be of special benefit to patients with aggressive and advanced stage disease and pave the way to the development of clinical trials using CX-4945 or other CK2 antagonists to manage CLL.
Journal ArticleDOI
Human CD4 T Cells From Thymus and Cord Blood Are Convertible Into CD8 T Cells by IL-4
Helena Nunes-Cabaço,Andreia Ramalho-dos-Santos,Ana R. Pires,Leila R. Martins,João T. Barata,Ana E. Sousa +5 more
TL;DR: It is shown that IL-4 induces proliferation-independent de novo synthesis of CD8αβ in human CD4 single-positive (SP) thymocytes, generating a stable CD8SP population that features a diverse TCRαβ repertoire, CD4 expression shut-down and ThPOK downregulation.
Posted ContentDOI
Cell division tracing combined with single-cell transcriptomics reveals new cell types and differentiation paths in the regenerating mouse lung
Leila R. Martins,Lina Sieverling,Michelle Michelhans,Chiara Schiller,Cihan Erkut,Sergio Triana,Stefan Fröhling,Lars Velten,Hanno Glimm,Claudia Scholl +9 more
TL;DR: In this paper , a comprehensive single-cell atlas of the distal lung was provided to characterize early transcriptional and cellular responses to defined epithelial injury, encompassing proliferation, differentiation, and cell-to-cell interactions.
Journal ArticleDOI
Single-cell RNA sequencing of mouse lower respiratory tract epithelial cells: A meta-analysis.
TL;DR: In this article , a single-cell transcriptome landscape of the mouse lower respiratory tract was established by performing a meta-analysis of seven different studies in which mouse lungs and trachea were analyzed by droplet and/or plate-based scRNA-seq technologies.