L
Leila R. Martins
Researcher at Instituto de Medicina Molecular
Publications - 20
Citations - 1247
Leila R. Martins is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Leukemia & PI3K/AKT/mTOR pathway. The author has an hindex of 13, co-authored 17 publications receiving 1128 citations. Previous affiliations of Leila R. Martins include German Cancer Research Center & University of Lisbon.
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Journal ArticleDOI
Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications
Bruno A. Cardoso,A. Girio,Catarina M. Henriques,Leila R. Martins,C. M. Santos,Ana Maria Silva,João T. Barata +6 more
TL;DR: This review focused on how deregulation of critical signaling pathways, in particular Notch, PI3K/Akt, MAPK, Jak/STAT and TGF-beta, may contribute to T-ALL.
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Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling.
Bruno A. Cardoso,Leila R. Martins,Cristina Santos,Lee M. Nadler,Vassiliki A. Boussiotis,Angelo A. Cardoso,Angelo A. Cardoso,João T. Barata +7 more
TL;DR: Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling by activatingmTOR signaling.
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On CK2 regulation of chronic lymphocytic leukemia cell viability
Leila R. Martins,Paulo Sérgio Lucio,Milene Costa da Silva,Paula Gameiro,Maria Gomes da Silva,João T. Barata +5 more
TL;DR: It is shown that inhibition of CK2 induces apoptosis of CLL cells, whereas it does not significantly impact normal lymphocytes, demonstrating the selectivity of the CK2 inhibitors toward leukemia cells.
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Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival.
Kolja Pocha,Andreas Mock,Carmen Rapp,Steffen Dettling,Rolf Warta,Christoph Geisenberger,Christine Jungk,Leila R. Martins,Niels Grabe,David E. Reuss,David E. Reuss,Juergen Debus,Andreas von Deimling,Andreas von Deimling,Amir Abdollahi,Andreas Unterberg,Christel Herold-Mende +16 more
TL;DR: The expression of surfactant metabolism-related genes (SFTPA1, SFTPB, and NAPSA) defines an inflamed subtype of lung adenocarcinoma brain metastases characterized by high abundance of TILs in close vicinity to tumor cells, a prolonged survival, and a tumor microenvironment which might be more accessible to immunotherapeutic approaches.
Journal ArticleDOI
Stk33 is required for spermatid differentiation and male fertility in mice.
Leila R. Martins,Raffaela K. Bung,Stefan Koch,Karsten Richter,Laura Schwarzmüller,Dorothee Terhardt,Bahtiyar Kurtulmus,Christof Niehrs,Arefeh Rouhi,Ingrid Lohmann,Gislene Pereira,Stefan Fröhling,Hanno Glimm,Claudia Scholl +13 more
TL;DR: It is reported that the serine/threonine kinase Stk33 is essential for the differentiation of round spermatids into functional sperm cells and male fertility and targeted deletion of StK33 in these cells recapitulates the defects observed in constitutive knockout mice, confirming a germ cell-intrinsic function.