L
Lena Brydon
Researcher at University College London
Publications - 35
Citations - 4673
Lena Brydon is an academic researcher from University College London. The author has contributed to research in topics: Blood pressure & Heart rate. The author has an hindex of 29, co-authored 35 publications receiving 4192 citations.
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Journal ArticleDOI
Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity
TL;DR: Inflammation-associated mood deterioration is reflected in changes in sACC activity and functional connectivity during evoked responses to emotional stimuli, suggesting a common pathophysiological basis for major depressive disorder and sickness- associated mood change and depression.
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Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middle-aged men and women
TL;DR: The revised UCLA loneliness scale was completed by 240 working men and women aged 47-59 years and related to affective state and neuroendocrine, cardiovascular, and inflammatory responses.
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Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans.
Lena Brydon,Neil A. Harrison,Neil A. Harrison,Cicely Walker,Andrew Steptoe,Hugo D. Critchley +5 more
TL;DR: These findings provide mechanistic insights into the interaction between inflammation and neurocognitive performance, specifically implicating circulating cytokines and midbrain dopaminergic nuclei in mediating the psychomotor consequences of systemic infection.
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Neural Origins of Human Sickness in Interoceptive Responses to Inflammation
Neil A. Harrison,Neil A. Harrison,Lena Brydon,Cicely Walker,Marcus A. Gray,Andrew Steptoe,Raymond J. Dolan,Hugo D. Critchley +7 more
TL;DR: These findings suggest that peripheral infection selectively influences central nervous system function to generate core symptoms of sickness and reorient basic motivational states.
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Acute inflammation and negative mood: mediation by cytokine activation.
TL;DR: It is concluded that S. typhi vaccination may be a useful model of mild inflammatory challenge, producing a significant transient cytokine-induced decrease in mood in the absence of any febrile response.