Lenka Stixová

TL;DR: It is found that hormone-induced DHSs were enriched within ± 50 kb of GR-responsive genes and displayed a broad spectrum of lifetimes upon hormone withdrawal, which have implications for corticosteroid function in vivo and for steroid therapies in various clinical settings.

TL;DR: Data indicate that the dynamics of recognition of UV‐damaged chromatin, and the nuclear arrangement of BMI1 protein can be influenced by acetylation and occur as an early event prior to the recruitment of HPβ to UV‐irradiated chromatin.

TL;DR: How ESCs might respond to DNA damage caused by genotoxic injury that might lead to unwanted genomic instability is discussed, and pluripotency-specific events that accompany DNA damage responses are demonstrated.

TL;DR: The half-life time of rRNA transcripts in two human-derived cell lines, HeLa and LEP (human embryonic fibroblasts), as well as in mouse NIH 3T3 cells is estimated; the primary transcripts seemed to be more stable in the human than in the murine cells.

TL;DR: This study analysed the trajectories of PML bodies using single‐particle tracking to identify specific nuclear structures with functional significance for acute promyelocytic leukaemia.