S
Soňa Legartová
Researcher at Academy of Sciences of the Czech Republic
Publications - 53
Citations - 807
Soňa Legartová is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 16, co-authored 50 publications receiving 679 citations.
Papers
More filters
Journal ArticleDOI
HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals.
Josef Večeřa,Eva Bártová,Jana Krejčí,Soňa Legartová,Denisa Komůrková,Jana Ruda-Kucerova,Tibor Štark,Eva Dražanová,Tomáš Kašpárek,Alexandra Šulcová,Frank J. Dekker,Wiktor Szymanski,Christian Seiser,Georg Weitzer,Raphael Mechoulam,Vincenzo Micale,Stanislav Kozubek +16 more
TL;DR: The results indicate that co‐regulation of H3K9ac by HDAC1 and HDAC3 is important to both embryonic brain development and neuro‐differentiation as well as the pathophysiology of a schizophrenia‐like phenotype.
Journal ArticleDOI
Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin
Gabriela Šustáčková,Stanislav Kozubek,Lenka Stixová,Soňa Legartová,Pavel Matula,Pavel Matula,Darya Yurevna Orlova,Eva Bártová +7 more
TL;DR: Data indicate that the dynamics of recognition of UV‐damaged chromatin, and the nuclear arrangement of BMI1 protein can be influenced by acetylation and occur as an early event prior to the recruitment of HPβ to UV‐irradiated chromatin.
Journal ArticleDOI
Recruitment of Oct4 Protein to UV-Damaged Chromatin in Embryonic Stem Cells
Eva Bártová,Gabriela Šustáčková,Lenka Stixová,Stanislav Kozubek,Soňa Legartová,Veronika Foltánková +5 more
TL;DR: How ESCs might respond to DNA damage caused by genotoxic injury that might lead to unwanted genomic instability is discussed, and pluripotency-specific events that accompany DNA damage responses are demonstrated.
Journal ArticleDOI
Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin
TL;DR: It is proposed that protein kinetics are likely influenced by several factors, including chromatin condensation, differentiation, local protein density, protein binding efficiency, and nuclear pattern.
Journal ArticleDOI
N6-Adenosine Methylation in RNA and a Reduced m3G/TMG Level in Non-Coding RNAs Appear at Microirradiation-Induced DNA Lesions
Alena Svobodová Kovaříková,Alena Svobodová Kovaříková,Lenka Stixová,Aleš Kovařík,Denisa Komůrková,Soňa Legartová,Paolo Fagherazzi,Paolo Fagherazzi,Eva Bártová +8 more
TL;DR: Overall, this work prefers a model in which m6A RNAs rapidly respond to radiation-induced stress and diffuse to the damaged sites and is preferred as a consequence of DNA damage, recognized by the nucleotide excision repair mechanism.