L
Leo E. Akioyamen
Researcher at University of Toronto
Publications - 19
Citations - 456
Leo E. Akioyamen is an academic researcher from University of Toronto. The author has contributed to research in topics: Familial hypercholesterolemia & Internal medicine. The author has an hindex of 8, co-authored 12 publications receiving 303 citations. Previous affiliations of Leo E. Akioyamen include McMaster University & International Council for the Exploration of the Sea.
Papers
More filters
Journal ArticleDOI
Estimating the prevalence of heterozygous familial hypercholesterolaemia: a systematic review and meta-analysis.
Leo E. Akioyamen,Jacques Genest,Shubham D. Shan,Rachel L Reel,Jordan M. Albaum,Anna Chu,Jack V. Tu +6 more
TL;DR: The authors' systematic review suggests that FH is a common disorder, affecting 1 in 250 individuals, and underscore the need for early detection and management to decrease CVD risk.
Journal ArticleDOI
Risk factors for cardiovascular disease in heterozygous familial hypercholesterolemia: A systematic review and meta-analysis.
Leo E. Akioyamen,Leo E. Akioyamen,Jacques Genest,Jacques Genest,Anna Chu,Anna Chu,Happy Inibhunu,Dennis T. Ko,Dennis T. Ko,Dennis T. Ko,Jack V. Tu,Jack V. Tu,Jack V. Tu +12 more
TL;DR: Several clinical risk factors are significantly and independently associated with CVD risk in patients with FH and should be targeted for modification.
Journal ArticleDOI
Genetic testing for familial hypercholesterolemia: Impact on diagnosis, treatment and cardiovascular risk.
Seohyuk Lee,Leo E. Akioyamen,Sumayah Aljenedil,Jean-Baptiste Rivière,Isabelle Ruel,Jacques Genest +5 more
TL;DR: DNA sequencing confirms the diagnosis of FH but has a poor yield in unselected patients whose sole criterion is an elevated LDL-C, and initiation and adherence to treatment is improved.
Journal ArticleDOI
Cardiovascular and cerebrovascular outcomes of long-term angiotensin receptor blockade: meta-analyses of trials in essential hypertension.
Leo E. Akioyamen,Mitchell Levine,Diana Sherifali,Daria O'Reilly,Daria O'Reilly,Claudia Frankfurter,Eleanor Pullenayegum,Ron Goeree,Ron Goeree,Bernice Tsoi,Bernice Tsoi +10 more
TL;DR: In this article, the authors conducted a systematic review and meta-analysis assessing the long-term effects of ARBs as a class on BP control, myocardial infarction, hospitalization for heart failure, cerebrovascular events (ie, stroke), cardiovascular mortality, and all-cause mortality.
Journal ArticleDOI
Risk of Ischemic Stroke and Peripheral Arterial Disease in Heterozygous Familial Hypercholesterolemia: A Meta-Analysis.
Leo E. Akioyamen,Leo E. Akioyamen,Jack V. Tu,Jack V. Tu,Jack V. Tu,Jacques Genest,Jacques Genest,Dennis T. Ko,Dennis T. Ko,Dennis T. Ko,Alexandre Coutin,Shubham D. Shan,Shubham D. Shan,Anna Chu,Anna Chu +14 more
TL;DR: Clinical and genetic diagnoses of HeFH were found to be associated with increased PAD risk and genetically confirmed HeFH may not confer an increased risk of ischemic stroke, and Modest associations may exist between LDL-C and ischeMIC stroke risk in HeFH.