Leo Paljärvi

TL;DR: According to radiologic, neurophysiologic, and muscle biopsy evidence most patients suffering from the severe postoperative failed back syndrome had dorsal ramus lesions in one or more segments covered by the scar and local paraspinal muscle atrophy at the corresponding segments.

TL;DR: The degree of dementia of the patients had a significant correlation only with neuronal loss in the medial part of the substantia nigra, suggesting that intact projections to the caudate nucleus and limbic and cortical areas are a prerequisite for normal cognitive functioning and their dysfunction leads to clinical dementia.

TL;DR: It is concluded that HSV tk gene therapy is safe and well tolerated and further trials are justified, especially with adenovirus vectors.

TL;DR: With neuropathological diagnosis as the point of reference, the accuracy of clinical diagnosis was studied in a series of 58 demented patients, and the value of Hachinski's Ischaemic Score in differentiating between Alzheimer's disease and vascular dementias was demonstrated.

TL;DR: The safety and feasibility of in vivo gene transfer to human malignant glioma was established with retro- and adenovirus vectors and Adenoviruses were more efficient than retroviruses in achieving in vitro gene transfer.