S
Seppo Ylä-Herttuala
Researcher at University of Eastern Finland
Publications - 846
Citations - 56582
Seppo Ylä-Herttuala is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Vascular endothelial growth factor & Angiogenesis. The author has an hindex of 76, co-authored 810 publications receiving 52219 citations. Previous affiliations of Seppo Ylä-Herttuala include University of California, San Diego & University of Jyväskylä.
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Journal ArticleDOI
Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.
Seppo Ylä-Herttuala,Wulf Palinski,Michael E. Rosenfeld,Sampath Parthasarathy,Thomas E. Carew,Susan Butler,Joseph L. Witztum,Daniel Steinberg +7 more
TL;DR: Three lines of evidence are presented that low density lipoproteins gently extracted from human and rabbit atherosclerotic lesions (lesion LDL) greatly resembles LDL that has been oxidatively modified in vitro.
Journal ArticleDOI
Low density lipoprotein undergoes oxidative modification in vivo
Wulf Palinski,Michael E. Rosenfeld,Seppo Ylä-Herttuala,Geoff C. Gurtner,Steve S. Socher,Susan Butler,Sampath Parthasarathy,Thomas E. Carew,Daniel Steinberg,Joseph L. Witztum +9 more
TL;DR: Three mutually supportive lines of evidence for oxidation of LDL in vivo are presented and autoantibodies against malondialdehyde-LDL (titers from 512 to greater than 4096) can be demonstrated in rabbit and human sera.
Journal ArticleDOI
Autoantibody against oxidised LDL and progression of carotid atherosclerosis.
Jukka T. Salonen,Seppo Ylä-Herttuala,Yamamoto R,Susan Butler,H. Korpela,Riitta Salonen,Kristiina Nyyssönen,Wulf Palinski,Joseph L. Witztum +8 more
TL;DR: The titre of autoantibodies to MDA-LDL was an independent predictor of the progression of carotid atherosclerosis in these Finnish men, providing further support for a role of oxidatively modified LDL in atherogenesis.
Journal ArticleDOI
Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions.
Seppo Ylä-Herttuala,Beth A. Lipton,Michael E. Rosenfeld,Terttu Särkioja,Teizo Yoshimura,Edward J. Leonard,Joseph L. Witztum,Daniel Steinberg +7 more
TL;DR: It is concluded that MCP-1 is strongly expressed in a small subset of cells in macrophage-rich regions of human and rabbit atherosclerotic lesions and may play an important role in the ongoing recruitment of monocyte-macrophages into developing lesions in vivo.
Journal ArticleDOI
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tuomas Tammela,Georgia Zarkada,Elisabet Wallgard,Aino Murtomäki,Steven Suchting,Maria Wirzenius,Marika Waltari,Mats Hellström,Tibor Schomber,Reetta Peltonen,Catarina Freitas,Antonio Duarte,Helena Isoniemi,Pirjo Laakkonen,Gerhard Christofori,Seppo Ylä-Herttuala,Masabumi Shibuya,Bronislaw Pytowski,Anne Eichmann,Christer Betsholtz,Kari Alitalo +20 more
TL;DR: It is demonstrated that VEGFR-3 is highly expressed in angiogenic sprouts, and genetic targeting or blocking of VEG FR-3 signalling with monoclonal antibodies results in decreased sprouting, vascular density, vessel branching and endothelial cell proliferation in mouse angiogenesis models, implicate VEGfr-3 as a regulator of vascular network formation.