L
Leo T. Chylack
Researcher at Brigham and Women's Hospital
Publications - 212
Citations - 13350
Leo T. Chylack is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Hexokinase & Population. The author has an hindex of 55, co-authored 212 publications receiving 12720 citations. Previous affiliations of Leo T. Chylack include Pfizer & Karolinska Institutet.
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Journal ArticleDOI
The Lens Opacities Classification System III
Leo T. Chylack,John K. Wolfe,D.M. Singer,M. C. Leske,Mark A. Bullimore,Ian Bailey,Judith Friend,D. Mccarthy,Suh Yuh Wu +8 more
TL;DR: The LOCS III is an improved LOCS system for grading slit-lamp and retroillumination images of age-related cataract and contains an expanded set of standards that were selected from the Longitudinal Study of Cataract slide library.
Journal ArticleDOI
The Lens Opacities Case-Control Study. Risk factors for cataract.
TL;DR: Dietary intake of riboflavin, vitamins C, E, and carotene, which have antioxidant potential, was protective for cortical, nuclear, and mixed cataract; intake of niacin, thiamine, and iron also decreased risk.
Journal ArticleDOI
Lens Opacities Classification System II (LOCS II)
Leo T. Chylack,M. Cristina Leske,D. Mccarthy,Patricia M. Khu,Toyohiko Kashiwagi,Robert D. Sperduto +5 more
TL;DR: Very good interobserver reproducibility of the clinical gradings at the slit lamp, excellent intraobserver reproducecibility, very good to excellent interob server reproducible of photographic gradings, and good agreement between clinical and photographic grading are obtained.
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Comparing self-reported and physician-reported medical history.
TL;DR: Self-reported medical history and medication use in a cataract case-control study of 1,380 persons in Boston, Massachusetts, suggests an accurate recall of medical and drug usage history in well-defined chronic conditions.
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Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease
Lee E. Goldstein,Julien Muffat,Robert A. Cherny,Robert D. Moir,Maria Ericsson,Xudong Huang,Christine Mavros,Jennifer A Coccia,Kyle Y. Fagét,Karlotta A Fitch,Colin L. Masters,Rudolph E. Tanzi,Leo T. Chylack,Ashley I. Bush +13 more
TL;DR: The hypothesis that molecular pathological findings associated with Alzheimer's disease overlap in the lens and brain is investigated to find out whether lens Aβ might promote regionally-specific lens protein aggregation, extracerebral amyloid formation, and supranuclear cataracts.