J
Julien Muffat
Researcher at Massachusetts Institute of Technology
Publications - 37
Citations - 5713
Julien Muffat is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 20, co-authored 33 publications receiving 4847 citations. Previous affiliations of Julien Muffat include Hospital for Sick Children & Harvard University.
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Journal ArticleDOI
A three-dimensional human neural cell culture model of Alzheimer’s disease
Se Hoon Choi,Young Hye Kim,Matthias Hebisch,Christopher Sliwinski,Seungkyu Lee,Carla D’Avanzo,Hechao Chen,Basavaraj Hooli,Caroline Asselin,Julien Muffat,Justin Klee,Can-wen Zhang,Brian J. Wainger,Michael Peitz,Dora M. Kovacs,Clifford J. Woolf,Steven L. Wagner,Rudolph E. Tanzi,Doo Yeon Kim +18 more
TL;DR: This work reports that FAD mutations in β-amyloid precursor protein and presenilin 1 are able to induce robust extracellular deposition of amyloid-β, including amyloids-β plaques, in a human neural stem-cell-derived three-dimensional (3D) culture system, and successfully recapitulated Alzheimer’s disease pathology in a single 3D human neural cell culture system.
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Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
Jacob H. Hanna,Albert W. Cheng,Krishanu Saha,Jongpil Kim,Christopher J. Lengner,Frank Soldner,John P. Cassady,Julien Muffat,Bryce W. Carey,Rudolf Jaenisch +9 more
TL;DR: The generation of validated “naïve” human ESCs will allow the molecular dissection of a previously undefined pluripotent state in humans and may open up new opportunities for patient-specific, disease-relevant research.
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Efficient derivation of microglia-like cells from human pluripotent stem cells
Julien Muffat,Yun Li,Bingbing Yuan,Maisam Mitalipova,Attya Omer,Attya Omer,Sean R. Corcoran,Grisilda Bakiasi,Grisilda Bakiasi,Li-Huei Tsai,Patrick Aubourg,Richard M. Ransohoff,Rudolf Jaenisch +12 more
TL;DR: In this paper, microglia-like cells from human embryonic stem (ES) and induced pluripotent stem (iPS) cells were derived using defined serum-free culture conditions.
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Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease
Lee E. Goldstein,Julien Muffat,Robert A. Cherny,Robert D. Moir,Maria Ericsson,Xudong Huang,Christine Mavros,Jennifer A Coccia,Kyle Y. Fagét,Karlotta A Fitch,Colin L. Masters,Rudolph E. Tanzi,Leo T. Chylack,Ashley I. Bush +13 more
TL;DR: The hypothesis that molecular pathological findings associated with Alzheimer's disease overlap in the lens and brain is investigated to find out whether lens Aβ might promote regionally-specific lens protein aggregation, extracerebral amyloid formation, and supranuclear cataracts.
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Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations
Christopher J. Lengner,Alexander A. Gimelbrant,Jennifer A. Erwin,Jennifer A. Erwin,Albert W. Cheng,Matthew G. Guenther,G. Grant Welstead,Raaji Alagappan,Garrett M. Frampton,Ping Xu,Julien Muffat,Sandro Santagata,Doug Powers,C. Brent Barrett,Richard A. Young,Jeannie T. Lee,Jeannie T. Lee,Rudolf Jaenisch,Maisam Mitalipova +18 more
TL;DR: Findings indicate that the human blastocyst contains pre-X-inactivation cells and that this state is preserved in vitro through culture under physiological oxygen.