Showing papers in "The Lancet in 2003"

TL;DR: The results seen with primary PTCA remained better than those seen with thrombolytic therapy during long-term follow-up, and were independent of both the type of throm bolytic agent used and whether or not the patient was transferred for primary P TCA.

TL;DR: In this article, the authors provide an overview of present knowledge about initiatives to changing medical practice and suggest that to change behaviour is possible, but this change generally requires comprehensive approaches at different levels (doctor, team practice, hospital, wider environment), tailored to specific settings and target groups.

TL;DR: An overview of present knowledge about initiatives to changing medical practice is provided, showing that none of the approaches for transferring evidence to practice is superior to all changes in all situations.

TL;DR: The reductions in major cardiovascular events with atorvastatin are large, given the short follow-up time, and may have implications for future lipid-lowering guidelines.

TL;DR: Patients' age was a strong predictor of surgical outcome, and the size and location of an aneurysm predict both surgical and endovascular outcomes.

TL;DR: Gut flora might be an essential factor in certain pathological disorders, including multisystem organ failure, colon cancer, and inflammatory bowel diseases, and Probiotics and prebiotics are known to have a role in prevention or treatment of some diseases.

TL;DR: Direct evidence is provided that cholesterol-lowering therapy is beneficial for people with diabetes even if they do not already have manifest coronary disease or high cholesterol concentrations and statin therapy should now be considered routinely for all diabetic patients at sufficiently high risk of major vascular events, irrespective of their initial cholesterol concentrations.

TL;DR: Current use of HRT is associated with an increased risk of incident and fatal breast cancer; the effect is substantially greater for oestrogen-progestagen combinations than for other types of H RT.

TL;DR: Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.

TL;DR: Cedesartan has a moderate impact in preventing admissions for CHF among patients who have heart failure and LVEF higher than 40%.

TL;DR: The importance of undernutrition as an underlying cause of child deaths associated with infectious diseases, the effects of multiple concurrent illnesses, and recognition that pneumonia and diarrhoea remain the diseases that are most often associated with child deaths as mentioned in this paper.

TL;DR: The findings show that the interventions needed to achieve the millennium development goal of reducing child mortality by two-thirds by 2015 are available, but that they are not being delivered to the mothers and children who need them.

TL;DR: The addition of candesartan to ACE inhibitor and other treatment leads to a further clinically important reduction in relevant cardiovascular events in patients with CHF and reduced left-ventricular ejection fraction.

TL;DR: There were no significant differences in total major cardiovascular events between regimens based on ACE inhibitors, calcium antagonists, or diuretics or beta blockers, although ACE-inhibitor-based regimens reduced blood pressure less.

TL;DR: The consistent clinical progression, shifting radiological infiltrates, and an inverted V viral-load profile suggest that worsening in week 2 is unrelated to uncontrolled viral replication but may be related to immunopathological damage.

TL;DR: Among patients with stable coronary heart disease without apparent heart failure, perindopril can significantly improve outcome, and these benefits were consistent in all predefined subgroups and secondary endpoints.

TL;DR: People, particularly in poor households, can be protected from catastrophic health expenditures by reducing a health system's reliance on out-of-pocket payments and providing more financial risk protection.

TL;DR: Current available monotherapies-interferon, lamivudine, and adefovir dipivoxil-very rarely eradicate the virus, but greatly reduce its replication, necroinflammatory histological activity, and progression of fibrosis.

TL;DR: Codesartan was generally well tolerated and significantly reduced cardiovascular deaths and hospital admissions for heart failure and there was no significant heterogeneity for candesartan results across the component trials.

TL;DR: The results suggest that carvedilol extends survival compared with metoprolol.

TL;DR: The results lend support to the hypothesis that telomere shortening in human beings contributes to mortality in many age-related diseases.

TL;DR: Re-analysis of the trials with the same measurements and definitions yielded highly consistent results, indicating that surgery is of some benefit for patients with 50-69% symptomatic stenosis, and highly beneficial for those with 70% symptome stenosis or greater but without near-occlusion.

TL;DR: It is believed that implantation of AC133+ stem cells to the heart is safe and might induce angiogenesis, thus improving perfusion of the infarcted myocardium.

TL;DR: The results suggest that the preventive effect of lactobacillus GG on atopic eczema extends beyond infancy, and not just during the first 2 years of life.

TL;DR: A systematic overview and meta-analysis of randomised controlled trials and observational studies for the efficacy and safety of electroconvulsive therapy with simulated ECT, ECT versus pharmacotherapy, and different forms of ECT for patients with depressive illness found ECT is an effective short-term treatment for depression.

TL;DR: Genetic analysis showed that the SARS CoV isolates from Guangzhou shared the same origin with those in other countries, and had a phylogenetic pathway that matched the spread of SARS to the other parts of the world.

TL;DR: It is shown that Stromal-cell-derived factor 1 (SDF-1) is sufficient to induce therapeutic stem-cell homing to injured myocardium and suggested a strategy for directed stem- cell engraftment into injured tissues.

TL;DR: An overview of the clinical aspects, management, and treatment options for von Hippel-Lindau disease is presented.

TL;DR: In this paper, contrast-enhanced cardiovascular magnetic resonance (CMR) and single photon emission computed tomography (SPECT) myocardial perfusion imaging was used to detect sub-endocardial infarcts that are missed by SPECT.