L
Leo Tjäderhane
Researcher at Helsinki University Central Hospital
Publications - 17
Citations - 1490
Leo Tjäderhane is an academic researcher from Helsinki University Central Hospital. The author has contributed to research in topics: Matrix metalloproteinase & Pulp (tooth). The author has an hindex of 14, co-authored 17 publications receiving 1380 citations. Previous affiliations of Leo Tjäderhane include University of Toronto.
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Journal ArticleDOI
Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation.
Timo Sorsa,Leo Tjäderhane,Yrjö T. Konttinen,Anneli Lauhio,Tuula Salo,Hsi-Ming Lee,Lorne M. Golub,David L. Brown,Päivi Mäntylä +8 more
TL;DR: MMP‐inhibitor (MMPI)‐drugs, such as doxycycline, can be used as adjunctive medication to augment both the scaling and root planing‐treatment of periodontitis locally and to reduce inflammation systematically.
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The role of matrix metalloproteinases in the oral environment.
TL;DR: A review of matrix metalloproteinases (MMPs) and their role in physiological and pathological extracellular matrix (ECM) remodeling and degradation processes in the oral environment is presented in this paper.
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Immunohistochemical identification of MMP-2 and MMP-9 in human dentin: correlative FEI-SEM/TEM analysis.
Annalisa Mazzoni,David H. Pashley,Franklin R. Tay,Pietro Gobbi,Giovanna Orsini,Alessandra Ruggeri,Marcela Carrilho,Marcela Carrilho,Leo Tjäderhane,Roberto Di Lenarda,Lorenzo Breschi +10 more
TL;DR: The results of the study contribute to reveal distinct distribution pattern of gelatinases and support the hypothesis that these enzymes are intrinsic constituents of the dentin organic matrix after decalcification.
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Matrix metalloproteinase-8 (MMP-8) in pulpal and periapical inflammation and periapical root-canal exudates.
TL;DR: The findings demonstrate the presence of M MP-8 in the inflamed pulp and periapical tissue, indicating that MMP-8 has a role in pulpal and peruapical inflammation, most likely participating in tissue extracellular matrix degradation.
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Matrix Metalloproteinase-13 (MMP-13, Collagenase-3) is Highly Expressed in Human Tooth Pulp
TL;DR: The results reveal that MMP-13 is expressed and synthesized in pulp tissue, an interesting feature considering the very limited expression of M MP-13 in normal adult tissues.