L
Leocadio Rodríguez-Mañas
Researcher at Carlos III Health Institute
Publications - 317
Citations - 15907
Leocadio Rodríguez-Mañas is an academic researcher from Carlos III Health Institute. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 55, co-authored 271 publications receiving 11324 citations. Previous affiliations of Leocadio Rodríguez-Mañas include European University of Madrid & Foundation for Biomedical Research.
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Journal ArticleDOI
Pro-inflammatory effects of early non-enzymatic glycated proteins in human mesothelial cells vary with cell donor's age
Leocadio Rodríguez-Mañas,Carolina Sánchez-Rodríguez,Susana Vallejo,Mariam El-Assar,Concepción Peiró,Veronica Azcutia,Nuria Matesanz,Carlos F. Sánchez-Ferrer,Julián Nevado +8 more
TL;DR: Evaluated the interactions between the age of the donor of the HPMCs and the pro‐inflammatory effects of Amadori adducts in those cells to determine how diabetes induces damage in the elderly.
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Drug Induced Liver Injury in Geriatric Patients Detected by a Two-Hospital Prospective Pharmacovigilance Program: A Comprehensive Analysis Using the Roussel Uclaf Causality Assessment Method
Laura Pedraza,Olga Laosa,Leocadio Rodríguez-Mañas,Diego F Gutiérrez-Romero,Jesús Frías,José A. Carnicero,Elena Ramírez +6 more
TL;DR: A prospective evaluation of drug-induced liver injury (DILI) in two tertiary hospitals was conducted through a pharmacovigilance program from laboratory signals at hospital (PPLSH) to determine the principal characteristics of DILI in patients older than 65 years.
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The “Metabolic biomarkers of frailty in older people with type 2 diabetes mellitus” (MetaboFrail) study: Rationale, design and methods
Riccardo Calvani,Leocadio Rodríguez-Mañas,Anna Picca,Federico Marini,Alessandra Biancolillo,Olga Laosa,Laura Pedraza,Jacopo Gervasoni,Aniello Primiano,Alfredo Miccheli,Isabelle Bourdel-Marchasson,Sophie C. Regueme,Roberto Bernabei,Emanuele Marzetti,Emanuele Marzetti,Alan J. Sinclair,Giovanni Gambassi +16 more
TL;DR: This work proposes an innovative approach for biomarker identification that couples multi-platform analytical determinations with chemometric modeling strategies and identifies metabolic biomarkers of frailty in functionally limited older persons with type 2 diabetes mellitus.
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Prospective Changes in the Distribution of Movement Behaviors Are Associated With Bone Health in the Elderly According to Variations in their Frailty Levels
Irene Rodríguez-Gómez,Asier Mañas,Jose Losa-Reyna,Leocadio Rodríguez-Mañas,Sebastien F. M. Chastin,Sebastien F. M. Chastin,Luis M. Alegre,Francisco García-García,Ignacio Ara +8 more
TL;DR: Increasing MVPA relative to the change in the other movement behaviors during a 4‐year period could perhaps produce bone health improvements in the elderly that do not worsen their frailty level.
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Nifedipine, losartan and captopril effects on hyperplasia of vascular smooth muscle from Ren-2 transgenic rats
Concepción Peiró,Javier Angulo,Javier Regadera,José L Llergo,Alberto Sánchez-Ferrer,Leocadio Rodríguez-Mañas,Carlos F. Sánchez-Ferrer +6 more
TL;DR: Hyperplasia of transgenic-derived vascular smooth muscle cells is not blocked by angiotensin-converting enzyme inhibitors or angiotENSin receptor antagonists, but these cells are more sensitive to the antiproliferative effects of nifedipine.