C
Concepción Peiró
Researcher at Autonomous University of Madrid
Publications - 86
Citations - 4430
Concepción Peiró is an academic researcher from Autonomous University of Madrid. The author has contributed to research in topics: Endothelium & Vascular smooth muscle. The author has an hindex of 33, co-authored 78 publications receiving 3747 citations. Previous affiliations of Concepción Peiró include Hospital Universitario La Paz.
Papers
More filters
Journal ArticleDOI
A Phase I Clinical Trial of the Treatment of Crohn’s Fistula by Adipose Mesenchymal Stem Cell Transplantation
Damián García-Olmo,Mariano García-Arranz,Dolores Herreros,Isabel Pascual,Concepción Peiró,José Antonio Rodríguez-Montes,José Antonio Rodríguez-Montes +6 more
TL;DR: The results indicate that the protocol is feasible and safe for the treatment of fistulas in Crohn’s disease, and is the first report of a clinical trial of cell therapy using autologous stem cells obtained from a lipoaspirate.
Journal ArticleDOI
High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation.
Olha Zhenyukh,Esther Civantos,Marta Ruiz-Ortega,Maria Soledad Sánchez,Clotilde Vázquez,Concepción Peiró,Jesús Egido,Sebastian Mas +7 more
TL;DR: Elevated BCAA blood levels can promote the activation of circulating PBMCs, by a mechanism that involving ROS production and NF‐&kgr;B pathway activation, which suggest that high concentrations of BCAA could exert deleterious effects on circulating blood cells and therefore contribute to the pro‐inflammatory and oxidative status observed in several pathophysiological conditions.
Journal ArticleDOI
Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation.
Leocadio Rodríguez-Mañas,Mariam El-Assar,Susana Vallejo,Pedro López-Dóriga,Joaquin Solís,Roberto Petidier,Manuel Montes,Julián Nevado,Marta Castro,Carmen Gomez-Guerrero,Concepción Peiró,Carlos F. Sánchez-Ferrer +11 more
TL;DR: It is concluded that the age‐dependent endothelial dysfunction in human vessels is due to the combined effect of oxidative stress and vascular wall inflammation.
Journal ArticleDOI
Mechanisms involved in the aging-induced vascular dysfunction.
Mariam El Assar,Javier C. Angulo,Susana Vallejo,Concepción Peiró,Carlos F. Sánchez-Ferrer,Leocadio Rodríguez-Mañas +5 more
TL;DR: Prevention or reversion of those mechanisms leading to endothelial dysfunction through life style modifications or pharmacological interventions could markedly improve cardiovascular health in older people.
Journal ArticleDOI
Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity
Tania Romacho,Veronica Azcutia,M. Vázquez-Bella,Nuria Matesanz,Elena Cercas,Julián Nevado,R. Carraro,Leocadio Rodríguez-Mañas,Carlos F. Sánchez-Ferrer,Concepción Peiró +9 more
TL;DR: Through its intrinsic NAMPT activity, ePBEF/NAMPT/visfatin appears to be a direct contributor to vascular inflammation, a key feature of atherothrombotic diseases linked to metabolic disorders.