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What the radiologist should know about artificial intelligence - an ESR white paper

Artificial Intelligence in Medicine: Where Are We Now?

Exploring Large-scale Public Medical Image Datasets.

In recent years, there has been enormous interest in applying artificial intelligence (AI) to radiology. Although some of this interest may have been driven by exaggerated expectations that the technology can outperform radiologists in some tasks, there is a growing body of evidence that illustrates its limitations in medical imaging. The true potential of the technique probably lies somewhere in the middle, and AI will ultimately play a key role in medical imaging in the future. The limitless power of computers makes AI an ideal candidate to provide the standardization, consistency, and dependability needed to support radiologists in their mission to provide excellent patient care. However, important roadblocks currently limit the expansion of this field in medical imaging. This article reviews some of the challenges and potential solutions to advance the field forward, with focus on the experience gained by hosting image-based competitions.

Challenges Related to Artificial Intelligence Research in Medical Imaging and the Importance of Image Analysis Competitions

The presence of confounding effects (or biases) is one of the most critical challenges in using deep learning to advance discovery in medical imaging studies. Confounders affect the relationship between input data (e.g., brain MRIs) and output variables (e.g., diagnosis). Improper modeling of those relationships often results in spurious and biased associations. Traditional machine learning and statistical models minimize the impact of confounders by, for example, matching data sets, stratifying data, or residualizing imaging measurements. Alternative strategies are needed for state-of-the-art deep learning models that use end-to-end training to automatically extract informative features from large set of images. In this article, we introduce an end-to-end approach for deriving features invariant to confounding factors while accounting for intrinsic correlations between the confounder(s) and prediction outcome. The method does so by exploiting concepts from traditional statistical methods and recent fair machine learning schemes. We evaluate the method on predicting the diagnosis of HIV solely from Magnetic Resonance Images (MRIs), identifying morphological sex differences in adolescence from those of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA), and determining the bone age from X-ray images of children. The results show that our method can accurately predict while reducing biases associated with confounders. The code is available at https://github.com/qingyuzhao/br-net .

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Training confounder-free deep learning models for medical applications.

Purpose The Radiological Society of North America (RSNA) Pediatric Bone Age Machine Learning Challenge was created to show an application of machine learning (ML) and artificial intelligence (AI) in medical imaging, promote collaboration to catalyze AI model creation, and identify innovators in medical imaging. Materials and Methods The goal of this challenge was to solicit individuals and teams to create an algorithm or model using ML techniques that would accurately determine skeletal age in a curated data set of pediatric hand radiographs. The primary evaluation measure was the mean absolute distance (MAD) in months, which was calculated as the mean of the absolute values of the difference between the model estimates and those of the reference standard, bone age. Results A data set consisting of 14 236 hand radiographs (12 611 training set, 1425 validation set, 200 test set) was made available to registered challenge participants. A total of 260 individuals or teams registered on the Challenge website. A total of 105 submissions were uploaded from 48 unique users during the training, validation, and test phases. Almost all methods used deep neural network techniques based on one or more convolutional neural networks (CNNs). The best five results based on MAD were 4.2, 4.4, 4.4, 4.5, and 4.5 months, respectively. Conclusion The RSNA Pediatric Bone Age Machine Learning Challenge showed how a coordinated approach to solving a medical imaging problem can be successfully conducted. Future ML challenges will catalyze collaboration and development of ML tools and methods that can potentially improve diagnostic accuracy and patient care. © RSNA, 2018 Online supplemental material is available for this article. See also the editorial by Siegel in this issue.

The RSNA Pediatric Bone Age Machine Learning Challenge.

There has been a steady escalation in the impact of Artificial Intelligence (AI) on Healthcare along with an increasing amount of progress being made in this field. While many entities are working on the development of significant deep learning models for the diagnosis of brain-related diseases, identifying precise images needed for model training and inference tasks is limited due to variation in DICOM fields which use free text to define things like series description, sequence and orientation \cite{willemink_koszek_hardell_wu_fleischmann_harvey_folio_summers_rubin_lungren_2020}. Detecting the orientation of brain MR scans (Axial/Sagittal/Coronal) remains a challenge due to these variations caused by linguistic barriers, human errors and de-identification - essentially rendering the tags unreliable. In this work, we propose a deep learning model that identifies the orientation of brain MR scans with near perfect accuracy.

https://medrxiv.org/content/10.1101/2021.08.17.21262189v1.full.pdf

Leon Chen

Papers

The RSNA Pediatric Bone Age Machine Learning Challenge.

Detecting orientation of Brain MR scans using deep learning