L
Leonard F. Bjeldanes
Researcher at University of California, Berkeley
Publications - 129
Citations - 7717
Leonard F. Bjeldanes is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Diindolylmethane & 3,3'-Diindolylmethane. The author has an hindex of 50, co-authored 129 publications receiving 7422 citations. Previous affiliations of Leonard F. Bjeldanes include University of California.
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Journal ArticleDOI
Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Leonard F. Bjeldanes,Jin-Young Kim,Karl R. Grose,James C. Bartholomew,Christopher A. Bradfield +4 more
TL;DR: The aromatic hydrocarbon responsiveness-receptor Kd values are reported and it is shown that indolo[3,2-b]carbazole (ICZ) is produced from I3C in yields on the order of 0.01% in vitro and, after oral intubation, in vivo, and ICZ and related condensation products appear responsible for the enzyme-inducing effects of dietary I2C.
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Indole-3-carbinol Inhibits the Expression of Cyclin-dependent Kinase-6 and Induces a G1 Cell Cycle Arrest of Human Breast Cancer Cells Independent of Estrogen Receptor Signaling
Carolyn M. Cover,S. Jean Hsieh,Susan H. Tran,Gunnell Hallden,Gloria S. Kim,Leonard F. Bjeldanes,Gary L. Firestone +6 more
TL;DR: The observations have uncovered a previously undefined antiproliferative pathway for I3C that implicates CDK6 as a target for cell cycle control in human breast cancer cells, and establish for the first time thatCDK6 gene expression can be inhibited in response to an extracellular antiprolifierative signal.
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Lipoxin A4: a new class of ligand for the Ah receptor.
TL;DR: The ability of the arachidonic acid metabolite, lipoxin A4, to bind to and activate the Ah receptor in Hepa-1 cells is reported and established as a new class of Ah receptors ligand, one that differs dramatically from classical Ah receptor ligands.
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Identification of the mutagens in cooked beef.
James S. Felton,Mark G. Knize,Nancy H. Shen,Brian D. Andresen,Leonard F. Bjeldanes,F. T. Hatch +5 more
TL;DR: The PhIP, which contributes the highest mass content to the cooked meat, but has the lowest mutagenic potency, might ultimately make a significant contribution to the carcinogenicity.
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Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells.
TL;DR: It is demonstrated that DIM can induce apoptosis in breast cancer cells independent of estrogen receptor status by a process that is mediated by the modulated expression of the Bax/Bcl-2 family of apoptotic regulatory factors.