Leonel Pérez

TL;DR: Age-related differences were identified in the prevalence of specific clinical manifestations as well as in their association with a confirmed DEN diagnosis of dengue virus infections in Nicaragua.

TL;DR: Interestingly, secondary infection was not significantly correlated with DHF/DSS, in contrast to previous studies in Southeast Asia, as evidenced by the analysis of this epidemic.

TL;DR: A cross-sectional study conducted on 984 and 313 hospitalized children with confirmed DENV infections during two time periods, respectively, in the same hospitals in Nicaragua provides new data to characterize the pathogenic potential of distinct DENV serotypes in human populations.

TL;DR: A 2‐year prospective study in schoolchildren 4–16 years old in the capital city of Managua demonstrates surprisingly high transmission of DENV in urban Nicaragua.

TL;DR: Given that saliva is a readily obtainable, noninvasive specimen, detection of DEN-specific salivary IgM should be considered a useful, cheaper diagnostic modality with similar sensitivity and specificity to IgM detection in serum.