Journal ArticleDOI
Clinical, epidemiologic, and virologic features of dengue in the 1998 epidemic in Nicaragua.
Eva Harris,Elsa Videa,Leonel Pérez,Erick Sandoval,Yolanda Tellez,Maria Angeles Pérez,Ricardo Cuadra,Julio Rocha,Wendy Idiaquez,Rosa Emelina Alonso,Maria A. Delgado,Luisa Amanda Campo,Francisco Acevedo,Alcides Gonzalez,Juan José Amador,Angel Balmaseda +15 more
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TLDR
Interestingly, secondary infection was not significantly correlated with DHF/DSS, in contrast to previous studies in Southeast Asia, as evidenced by the analysis of this epidemic.Abstract:
From July to December 1998, a hospital- and health center-based surveillance system for dengue was established at selected sites in Nicaragua to better define the epidemiology of this disease. Demographic and clinical information as well as clinical laboratory results were obtained, and virus isolation, reverse transcriptase-polymerase chain reaction, and serologic assays were performed. World Health Organization criteria were used to classify disease severity; however, a number of patients presented with signs of shock in the absence of thrombocytopenia or hemoconcentration. Therefore, a new category was designated as "dengue with signs associated with shock" (DSAS). Of 1,027 patients enrolled in the study, 614 (60%) were laboratory-confirmed as positive cases; of these, 268 (44%) were classified as dengue fever (DF); 267 (43%) as DF with hemorrhagic manifestations (DFHem); 40 (7%) as dengue hemorrhagic fever (DHF); 20 (3%) as dengue shock syndrome (DSS); and 17 (3%) as DSAS. Interestingly, secondary infection was not significantly correlated with DHF/DSS, in contrast to previous studies in Southeast Asia. DEN-3 was responsible for the majority of cases, with a minority due to DEN-2; both serotypes contributed to severe disease. As evidenced by the analysis of this epidemic, the epidemiology of dengue can differ according to geographic region and viral serotype.read more
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Journal ArticleDOI
Global spread and persistence of dengue.
Jennifer L. Kyle,Eva Harris +1 more
TL;DR: This review explores the human, mosquito, and viral factors that contribute to the global spread and persistence of dengue, as well as the interaction between the three spheres, in the context of ecological and climate changes.
Journal ArticleDOI
Dengue Virus Pathogenesis: an Integrated View
TL;DR: A personalized approach to the study of pathogenesis will elucidate the basis of individual risk for development of DHF and DSS as well as identify the genetic and environmental bases for differences in risk forDevelopment of severe disease.
Journal ArticleDOI
Antibody-dependent enhancement of severe dengue disease in humans
Leah C. Katzelnick,Lionel Gresh,M. Elizabeth Halloran,M. Elizabeth Halloran,Juan Carlos Mercado,Guillermina Kuan,Aubree Gordon,Angel Balmaseda,Eva Harris +8 more
TL;DR: Using multiple statistical approaches to study a long-term pediatric cohort in Nicaragua, it is shown that risk of severe dengue disease is highest within a narrow range of preexisting anti-DENV antibody titers, which has major implications for vaccines against flaviviruses.
Journal ArticleDOI
Secondary infection as a risk factor for dengue hemorrhagic fever/dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection
TL;DR: This review is focused on the etiological role of secondary infections (SI) and mechanisms of ADE, which results in an increased number of infected cells and increased viral output per cell at the late illness stage.
Journal ArticleDOI
Dengue fever: new paradigms for a changing epidemiology.
TL;DR: This paper reviews the changing epidemiology of the disease, focusing on host and societal factors and drawing on national and regional journals as well as international publications, and selected areas where the literature raises challenges to prevailing views and those that are key for improved service delivery in poor countries.
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Journal ArticleDOI
Dengue and Dengue Hemorrhagic Fever
TL;DR: A review of the changing epidemiology of dengue and hemorrhagic fever by geographic region, the natural history and transmission cycles, clinical diagnosis of both Dengue fever and DVF, serologic and virologic laboratory diagnoses, pathogenesis, surveillance, prevention, and control can be found in this paper.
Dengue and dengue hemorrhagic fever.
TL;DR: A major challenge for public health officials in all tropical areas of the world is to devleop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever.
Journal ArticleDOI
Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses.
D H Clarke,J Casals +1 more
TL;DR: A description of the procedures currently in use in The Rockefeller Foundation Virus Laboratories, some of which were initially developed elsewhere; of those developed in this laboratory, most aspects have not been previously reported.
Journal ArticleDOI
Pathogenesis of dengue: challenges to molecular biology
TL;DR: This work has identified a severe syndrome, dengue hemorrhagic fever/dengue shock syndrome, in Southeast Asian children, which recently has also been identified in children infected with the virus in Puerto Rico.
Journal ArticleDOI
Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate with Disease Severity
David W. Vaughn,Sharone Green,Siripen Kalayanarooj,Bruce L. Innis,Suchitra Nimmannitya,Saroj Suntayakorn,Timothy P. Endy,Boonyos Raengsakulrach,Alan L. Rothman,Francis A. Ennis,Ananda Nisalak +10 more
TL;DR: Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified, and increased dengue disease severity correlated with high viremia titer, secondary d Dengue virus infection, and DEN-2 virus type.