Leonid B. Katsnelson

TL;DR: D duplex models mimic (patho-)physiological mechano-electric interactions in heterogeneous myocardium at the multicellular level, and in an environment that allows one to control mechanical, electrical and pharmacological parameters.

TL;DR: A mathematical model for the regulation of mechanical activity in cardiac muscle has been developed based on a three-element rheological model of this muscle taking into account the results of extensive mechanical tests that involved the recording of length-force and force-velocity relations and muscle responses to short-time deformations during various phases of the contraction-relaxation cycle.

TL;DR: A theoretical rule-based model for anatomy and fibre orientation of the left ventricle (LV) of the heart and to compare it with experimental data shows good qualitative agreement between the simulated fibre orientation field and the experimental data on LV anisotropy.

TL;DR: It is shown in the framework of the model that myocardium mechanics may significantly enhance arrhythmogenicity of the calcium overload and several approaches are designed in the model and compared to each other for recovery of the validMyocardium electrical and mechanical performance in the case of the partially suppressed sodium-potassium pump.

TL;DR: The results suggest that the normal electrical activation sequence in the heart requires matching mechanical and electrical heterogeneity for optimal cardiac performance and mechanical modulation of Ca2+ handling is a key mechanism of MEF in heterogeneous myocardium, which contributes to the matching of local mechanical and/or electrical activity to global hemodynamic demand.