L
Leonor Morgado
Researcher at University of Lausanne
Publications - 3
Citations - 158
Leonor Morgado is an academic researcher from University of Lausanne. The author has contributed to research in topics: T cell & Janus kinase. The author has an hindex of 3, co-authored 3 publications receiving 112 citations.
Papers
More filters
Journal ArticleDOI
Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo
Giorgia Rota,Charlène Niogret,Anh Thu Dang,Cristina Ramon Barros,Nicolas Pierre Fonta,Nicolas Pierre Fonta,Francesca Alfei,Leonor Morgado,Dietmar Zehn,Walter Birchmeier,Eric Vivier,Greta Guarda,Greta Guarda +12 more
TL;DR: It is shown that Shp-2 is dispensable in T cells for globally establishing exhaustion and for PD-1 signaling in vivo, and the existence of redundant mechanisms downstream of inhibitory receptors is revealed.
Journal ArticleDOI
The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.
Wilson Castro,Sonia T. Chelbi,Sonia T. Chelbi,Charlène Niogret,Cristina Ramon-Barros,Suzanne P. M. Welten,Kevin Osterheld,Haiping Wang,Giorgia Rota,Leonor Morgado,Eric Vivier,Miro E. Raeber,Onur Boyman,Mauro Delorenzi,Mauro Delorenzi,David Barras,Ping-Chih Ho,Annette Oxenius,Greta Guarda,Greta Guarda +19 more
TL;DR: It is found that deletion of Rfx7 leads to a decrease in natural killer cell maintenance and immunity in vivo, and RFX7 emerges as a novel transcriptional regulator of NK cell homeostasis and metabolic quiescence.
Journal ArticleDOI
T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels
Giorgia Rota,Kristina Ludigs,Stefanie Siegert,Aubry Tardivel,Leonor Morgado,Walter Reith,Aude De Gassart,Greta Guarda +7 more
TL;DR: Data show that Nlrc5 deficiency, despite significantly affecting MHCI transcription and Ag display, is not sufficient to hinder T cell activation, underlining the robustness of the T cell priming process by activated DCs.